_EC 1.1.1.30 3-hydroxybutyrate dehydrogenase. 17 PDB entries  
EC 1.-.-.- Oxidoreductases. [7,297 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,523 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,373 PDB entries]
EC 1.1.1.30 3-hydroxybutyrate dehydrogenase. [17 PDB entries]    
1wmb

Reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + Nadh.
 


(R)-3-hydroxybutanoate
+
NAD(+)
=
acetoacetate
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): D-beta-hydroxybutyrate dehydrogenase.
Comments: Also oxidizes other 3-hydroxymonocarboxylic acids.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 17 PDB entries in enzyme class E.C.1.1.1.30

  PDB code Protein
1wmb
Crystal structure of NAD dependent d-3-hydroxybutylate dehyd
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (260 residues) CATH domain: 3.40.50.720
1x1t
Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (236 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2ag5
Crystal structure of human dhrs6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dhrs6. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (246 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2q2q
Structure of d-3-hydroxybutyrate dehydrogenase from pseudomo
Source: Pseudomonas putida. Organism_taxid: 303. Gene: bdha. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (250 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2q2v
Structure of d-3-hydroxybutyrate dehydrogenase from pseudomo
Source: Pseudomonas putida. Organism_taxid: 303. Gene: bdha. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (255 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2zea
Crystal structure of alcaligenes faecalis d-3-hydroxybutyrat dehydrogenase in complex with NAD+ and acetate
Source: Alcaligenes faecalis. Organism_taxid: 511
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group ACT is 57.14% similar to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
2ztl
Closed conformation of d-3-hydroxybutyrate dehydrogenase com with NAD+ and l-3-hydroxybutyrate
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group 3HL corresponds to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
2ztm
T190s mutant of d-3-hydroxybutyrate dehydrogenase
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (255 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group 3HL corresponds to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
2ztu
T190a mutant of d-3-hydroxybutyrate dehydrogenase complexed with NAD+
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (235 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2ztv
The binary complex of d-3-hydroxybutyrate dehydrogenase with
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group GOL is 62.50% similar to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
3eew
Crystal structure of d-3-hydroxybutyrate dehydrogenase, prep the presence of the substrate d-3-hydroxybutyrate and NAD+
Source: Alcaligenes faecalis. Organism_taxid: 511
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group 3HL corresponds to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
3v2h
The crystal structure of d-beta-hydroxybutyrate dehydrogenas sinorhizobium meliloti
Source: Sinorhizobium meliloti. Organism_taxid: 266834. Strain: 1021. Gene: bdha, rb1136, smb21010. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (232 residues) CATH domain: 3.40.50.720
3vdq
Crystal structure of alcaligenes faecalis d-3-hydroxybutyrat dehydrogenase in complex with NAD(+) and acetate
Source: Alcaligenes faecalis. Organism_taxid: 511
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group ACT is 57.14% similar to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
3vdr
Crystal structure of d-3-hydroxybutyrate dehydrogenase, prep the presence of the substrate d-3-hydroxybutyrate and NAD(+
Source: Alcaligenes faecalis. Organism_taxid: 511
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group 3HR corresponds to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
3w8d
Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
Source: Alcaligenes faecalis. Organism_taxid: 511. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group DXX is 66.67% similar to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
3w8e
Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d- hydroxybutyrate
Source: Alcaligenes faecalis. Organism_taxid: 511. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group 3HR corresponds to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)
3w8f
Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor m
Source: Alcaligenes faecalis. Organism_taxid: 511. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group MLA is 75.00% similar to enzyme reactant (R)-3-hydroxybutanoate
  Het Group NAD corresponds to enzyme reactant NAD(+)