_EC 1.1.1.3 Homoserine dehydrogenase. 6 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,873 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,684 PDB entries]
EC 1.1.1.3 Homoserine dehydrogenase. [6 PDB entries]    
1ebf

Pathway: Threonine Biosynthesis
Reaction: L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.
 


L-homoserine
+
NAD(P)(+)
=
L-aspartate 4-semialdehyde
+
NAD(P)H
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of Ec 2.7.2.4.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.1.1.1.3

  PDB code Protein
1ebf
Homoserine dehydrogenase from s. Cerevisiae complex with NAD+
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: hom6p. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (358 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligand:   Het Group NAD is 91.00% similar to enzyme reactant NADP(+)
1ebu
Homoserine dehydrogenase complex with NAD analogue and l- homoserine
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: hom6p. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (358 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligands:   Het Group HSE corresponds to enzyme reactant L-homoserine
  Het Group NDA is 89.00% similar to enzyme reactant NADP(+)
1q7g
Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: hom6, yjr139c or j2132. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (358 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligand:   Het Group NHO is 75.00% similar to enzyme reactant NADP(+)
1tve
Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: hom6. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (358 residues) CATH domains: 3.40.50.720 3.30.360.10
2ejw
Homoserine dehydrogenase from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, E, F (331 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligand:   Het Group GOL is 40.00% similar to enzyme reactant L-homoserine
3mtj
The crystal structure of a homoserine dehydrogenase from thi denitrificans to 2.15a
Source: Thiobacillus denitrificans. Organism_taxid: 292415. Strain: atcc 25259. Gene: tbd_0843. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (431 residues) CATH domains: 3.40.50.720 3.30.360.10 3.30.70.260