_EC 1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase. 10 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,685 PDB entries]
EC 1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase. [10 PDB entries]    
1ps6

Reaction: 4-phosphonooxy-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO(2) + Nadh.
 


4-phosphonooxy-L-threonine
+
NAD(+)
=
3-amino-2-oxopropyl phosphate
+
CO(2)
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 4-(phosphohydroxy)-L-threonine dehydrogenase. L-threonine 4-phosphate dehydrogenase. NAD(+)-dependent threonine 4-phosphate dehydrogenase.
Comments: The product of the reaction undergoes decarboxylation to give 3-amino-2-oxopropyl phosphate. The enzyme is part of the biosynthesis pathway of the coenzyme pyridoxal 5'-phosphate found in anaerobic bacteria.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 10 PDB entries in enzyme class E.C.1.1.1.262

  PDB code Protein
1ps6
Crystal structure of e.Coli pdxa
Source: Escherichia coli. Organism_taxid: 562. Gene: pdxa or b0052. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (328 residues) CATH domain: 3.40.718.10
Bound ligand:   Het Group 4TP corresponds to enzyme reactant 4-(phosphonooxy)-L-threonine
1ps7
Crystal structure of e.Coli pdxa
Source: Escherichia coli. Organism_taxid: 562. Gene: pdxa or b0052. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (328 residues) CATH domain: 3.40.718.10
1ptm
Crystal structure of e.Coli pdxa
Source: Escherichia coli. Organism_taxid: 562. Gene: pdxa or b0052. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (329 residues) CATH domain: 3.40.718.10
1r8k
Pdxa protein; NAD-dependent dehydrogenase/carboxylase; subunit of pyridoxine phosphate biosynthetic protein pdxj- pdxa [salmonella typhimurium]
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: pdxa, stm0090. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (327 residues) CATH domain: 3.40.718.10
1yxo
Crystal structure of pyridoxal phosphate biosynthetic protei pa0593
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: pdxa1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (328 residues) CATH domain: 3.40.718.10
2hi1
The structure of a putative 4-hydroxythreonine-4-phosphate dehydrogenase from salmonella typhimurium.
Source: Salmonella typhimurium. Organism_taxid: 99287. Strain: lt2. Gene: pdxa2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (325 residues) CATH domain: 3.40.718.10
3lxy
Crystal structure of 4-hydroxythreonine-4-phosphate dehydrog yersinia pestis co92
Source: Yersinia pestis. Organism_taxid: 632. Gene: pdxa, ypo0493, y3682, yp_3686. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (329 residues) CATH domain: 3.40.718.10
3tsn
4-hydroxythreonine-4-phosphate dehydrogenase from campylobac
Source: Campylobacter jejuni subsp. Jejuni. Organism_taxid: 192222. Strain: nctc 11168. Gene: cj1239, pdxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (364 residues) CATH domain: 3.40.718.10
4aty
Crystal structure of a terephthalate 1,2-cis- dihydrodioldehydrogenase from burkholderia xenovorans lb400
Source: Burkholderia xenovorans lb400. Organism_taxid: 266265. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (309 residues) CATH domain: 3.40.718.10
Bound ligand:   Het Group BME is 40.00% similar to enzyme product CO(2)
4jqp
X-ray crystal structure of a 4-hydroxythreonine-4-phosphate dehydrogenase from burkholderia phymatum
Source: Burkholderia phymatum. Organism_taxid: 391038. Strain: stm815. Gene: pdxa. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (330 residues) CATH domain: 3.40.718.10
Bound ligand:   Het Group EDO is 40.00% similar to enzyme product 3-amino-2-oxopropyl