_EC 1.1.1.23 Histidinol dehydrogenase. 7 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,685 PDB entries]
EC 1.1.1.23 Histidinol dehydrogenase. [7 PDB entries]    
1k75

Pathway: Histidine Biosynthesis (late stages)
Reaction: L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 Nadh.
 


L-histidinol
+ H(2)O
+
2 × NAD(+)
=
L-histidine
+
2 × NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Also oxidizes L-histidinal. The Neurospora enzyme also catalyzes the reactions of Ec 3.5.4.19 and Ec 3.6.1.31.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.1.1.1.23

  PDB code Protein
1k75
The l-histidinol dehydrogenase (hisd) structure implicates d swapping and gene duplication.
Source: Escherichia coli. Organism_taxid: 562. Gene: hisd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (431 residues) CATH domains: 3.40.50.1980 Unassigned 3.40.50.1980
1kae
L-histidinol dehydrogenase (hisd) structure complexed with l histidinol (substrate), zinc and NAD (cofactor)
Source: Escherichia coli. Organism_taxid: 562. Gene: hisd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (434 residues) CATH domains: 3.40.50.1980 3.40.50.1980
Bound ligands:   Het Group HSO corresponds to enzyme reactant L-histidinol
  Het Group NAD corresponds to enzyme reactant NAD(+)
1kah
L-histidinol dehydrogenase (hisd) structure complexed with l-histidine (product), zn and NAD (cofactor)
Source: Escherichia coli. Organism_taxid: 562. Gene: hisd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (431 residues) CATH domains: 3.40.50.1980 3.40.50.1980
Bound ligand:   Het Group HIS corresponds to enzyme product L-histidine
1kar
L-histidinol dehydrogenase (hisd) structure complexed with histamine (inhibitor), zinc and NAD (cofactor)
Source: Escherichia coli. Organism_taxid: 562. Gene: hisd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (431 residues) CATH domains: 3.40.50.1980 3.40.50.1980
Bound ligand:   Het Group HSM is 80.00% similar to enzyme reactant L-histidinol
4g07
The crystal structure of the c366s mutant of hdh from brucel
Source: Brucella suis 1330. Organism_taxid: 204722. Strain: 1330. Gene: hisd, br0252, bs1330_i0253. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (427 residues) CATH domain: 3.40.50.1980
4g09
The crystal structure of the c366s mutant of hdh from brucel complex with a substituted benzyl ketone
Source: Brucella suis. Organism_taxid: 204722. Strain: 1330. Gene: hisd, br0252, bs1330_i0253. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (432 residues) CATH domain: 3.40.50.1980
Bound ligand:   Het Group 0VD is 40.00% similar to enzyme reactant L-histidinol
4gic
Crystal structure of a putative histidinol dehydrogenase (ta 014034) from methylococcus capsulatus
Source: Methylococcus capsulatus. Organism_taxid: 243233. Strain: bath. Gene: hisd, mca1963. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (382 residues) CATH domain: 3.40.50.1980