_EC 1.1.1.205 Imp dehydrogenase. 46 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,574 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,862 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,670 PDB entries]
EC 1.1.1.205 Imp dehydrogenase. [46 PDB entries]    
1ak5

Pathway: AMP and GMP Biosynthesis
Reaction: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + Nadh.
 


Inosine 5'-phosphate
+
NAD(+)
+ H(2)O
=
xanthosine 5'-phosphate
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Imp oxidoreductase. Inosinate dehydrogenase. Inosine 5'-monophosphate dehydrogenase. Inosine monophosphate oxidoreductase. Inosinic acid dehydrogenase.
Comments: The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. Formerly Ec 1.2.1.14.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 46 PDB entries in enzyme class E.C.1.1.1.205

  PDB code Protein
1ak5
Inosine monophosphate dehydrogenase (impdh) from tritrichomo
Source: Tritrichomonas foetus. Organism_taxid: 5724. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (329 residues) CATH domain: 3.20.20.70
1b3o
Ternary complex of human type-ii inosine monophosphate dehydrogenase with 6-cl-imp and selenazole adenine dinucleotide
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: type ii isozyme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (307 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group CPR is 95.00% similar to enzyme reactant Inosine 5'-phosphate
  Het Group SAE is 67.00% similar to enzyme reactant NAD(+)
1eep
2.4 a resolution crystal structure of borrelia burgdorferi i monphosphate dehydrogenase in complex with a sulfate ion
Source: Borrelia burgdorferi. Lyme disease spirochete. Organism_taxid: 139. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (314 residues) CATH domain: 3.20.20.70
1jcn
Binary complex of human type-i inosine monophosphate dehydro with 6-cl-imp
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: type i isozyme. Gene: impdh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (395 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group CPR is 95.65% similar to enzyme reactant Inosine
1jr1
Crystal structure of inosine monophosphate dehydrogenase in with mycophenolic acid
Source: Cricetulus griseus. Chinese hamster. Organism_taxid: 10029. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (436 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
1lrt
Crystal structure of ternary complex of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase: structural characterization of NAD+ site in microbial enzyme
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (338 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine 5'-phosphate
1me7
Inosine monophosphate dehydrogenase (impdh) from tritrichomo with rvp and moa bound
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (365 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group RVP is 83.33% similar to enzyme reactant Inosine
1me8
Inosine monophosphate dehydrogenase (impdh) from tritrichomo with rvp bound
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (357 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group RVP is 83.33% similar to enzyme reactant Inosine
1me9
Inosine monophosphate dehydrogenase (impdh) from tritrichomonas foetus with imp bound
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (350 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine 5'-phosphate
1meh
Inosine monophosphate dehydrogenase (impdh) from tritrichomo with imp and moa bound
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (354 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
1mei
Inosine monophosphate dehydrogenase (impdh) from tritrichomonas foetus with xmp and mycophenolic acid bound
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (351 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group XMP corresponds to enzyme product xanthosine 5'-phosphate
1mew
Inosine monophosphate dehydrogenase (impdh) from tritrichomo with xmp and NAD bound
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (344 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group XMP corresponds to enzyme product xanthosine
1mwf
An immunosuppressive agent forms a transition state analog complex of imp dehydrogenase
Source: Tritrichomonas foetus. Gene: impdh. Expressed in: escherichia coli.
Chains: A, B, C, D (362 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group MZP is 87.00% similar to enzyme reactant Inosine 5'-phosphate
1nf7
Ternary complex of the human type ii inosine monophosphate dedhydrogenase with ribavirin monophosphate and c2- mycophenolic adenine dinucleotide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: impdh2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (454 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group MYD is 46.00% similar to enzyme reactant Inosine 5'-phosphate
  Het Group RVP is 41.00% similar to enzyme reactant NAD(+)
1nfb
Ternary complex of the human type ii inosine monophosphate dedhydrogenase with 6cl-imp and NAD
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: impdh2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (396 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group CPR is 95.65% similar to enzyme reactant Inosine
  Het Group NAD corresponds to enzyme reactant NAD(+)
1pvn
The crystal structure of the complex between imp dehydrogenase catalytic domain and a transition state analogue mzp
Source: Tritrichomonas foetus. Organism_taxid: 5724. Gene: impdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (362 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group MZP is 87.00% similar to enzyme reactant Inosine 5'-phosphate
1vrd
Crystal structure of inosine-5'-monophosphate dehydrogenase from thermotoga maritima at 2.18 a resolution
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: tm1347. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (321 residues) CATH domain: 3.20.20.70
1zfj
Inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) fr streptococcus pyogenes
Source: Streptococcus pyogenes. Organism_taxid: 1314. Expressed in: streptococcus pyogenes. Expression_system_taxid: 1314.
Chain: A (477 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
2cu0
Crystal structure of inosine-5'-monophosphate dehydrogenase pyrococcus horikoshii ot3
Source: Pyrococcus horikoshii. Organism_taxid: 53953. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (358 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group XMP corresponds to enzyme product xanthosine
3ffs
The crystal structure of cryptosporidium parvum inosine-5'- monophosphate dehydrogenase
Source: Cryptosporidium parvum. Organism_taxid: 5807. Gene: impdh, 56k.02. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (301 residues) CATH domain: 3.20.20.70
3khj
C. Parvum inosine monophosphate dehydrogenase bound by inhib
Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa-ii. Gene: cgd6_20, guab. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (302 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
3r2g
Crystal structure of inosine 5' monophosphate dehydrogenase legionella pneumophila
Source: Legionella pneumophila subsp. Pneumoph organism_taxid: 272624. Strain: philadelphia 1 / atcc 33152 / dsm 7513. Gene: ipg2843, lpg2843. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (323 residues) CATH domain: 3.20.20.70
3tsb
Crystal structure of inosine-5'-monophosphate dehydrogenase bacillus anthracis str. Ames
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: guab, bas0011, ba_0008, gbaa_0008. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (490 residues) CATH domain: 3.20.20.70
3tsd
Crystal structure of inosine-5'-monophosphate dehydrogenase bacillus anthracis str. Ames complexed with xmp
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: guab, bas0011, ba_0008, gbaa_0008. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (442 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group XMP corresponds to enzyme product xanthosine
3usb
Crystal structure of bacillus anthracis inosine monophosphat dehydrogenase in the complex with imp
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: guab, ba_0008, bas0011, gbaa_0008. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (442 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
3zfh
Crystal structure of pseudomonas aeruginosa inosine 5'-monop dehydrogenase
Source: Pseudomonas aeruginosa pao1. Organism_taxid: 208964. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chain: A (299 residues) CATH domain: 3.20.20.70
4af0
Crystal structure of cryptococcal inosine monophosphate dehydrogenase
Source: Cryptococcus neoformans. Organism_taxid: 235443. Variant: grubii h99. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B (395 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4avf
Crystal structure of pseudomonas aeruginosa inosine 5'- monophosphate dehydrogenase
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pa01. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C, D (314 residues) CATH domain: 3.20.20.70
4dqw
Crystal structure analysis of pa3770
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: atcc 15692 / pao1 / 1c / prs 101 / lmg 12228. Gene: guab, pa3770. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (415 residues) CATH domains: 3.20.20.70 3.10.580.10
Bound ligand:   Het Group ATP is 68.75% similar to enzyme reactant Inosine
4fez
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae, mutant
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (316 residues) CATH domain: 3.20.20.70
4ff0
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae, mutant, complexed with imp
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (334 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4fo4
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae, mutant, complexed with imp and mycophenolic acid
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (348 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4fxs
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae with imp and mycophenolic acid
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (467 residues) CATH domains: 3.20.20.70 3.10.580.10
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4hlv
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae, mutant, in complex with NAD and imp
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (342 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group IMP corresponds to enzyme reactant Inosine
  Het Group NAJ corresponds to enzyme reactant NAD(+)
4ix2
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae, mutant, complexed with imp
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: guab, vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (334 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4ixh
Crystal structure of the catalytic domain of the inosine mon dehydrogenase from cryptosporidium parvum
Source: Cryptosporidium parvum. Organism_taxid: 5807. Gene: 56k.02, cgd6_20. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (336 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4mjm
Crystal structure of the inosine 5'-monophosphate dehydrogen a short internal deletion of cbs domain from bacillus anthr ames
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: guab, ba_0008, bas0011, gbaa_0008. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (328 residues) CATH domain: 3.20.20.70
4mxs
Crystal structure of the inosine 5'-monophosphate dehydrogen an internal deletion of the cbs domain from bacillus anthra ames complexed with inhibitor d67
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: bas0011, ba_0008, gbaa_0008, guab. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (337 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4my1
Crystal structure of the inosine 5'-monophosphate dehydrogen a internal deletion of cbs domain from bacillus anthracis s complexed with p68
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: bas0011, ba_0008, gbaa_0008, guab. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H (349 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4my8
Crystal structure of the inosine 5'-monophosphate dehydrogen an internal deletion of the cbs domain from bacillus anthra ames complexed with inhibitor q21
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: guab, ba_0008, bas0011, gbaa_0008. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (335 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4mya
Crystal structure of the inosine 5'-monophosphate dehydrogen an internal deletion of the cbs domain from bacillus anthra ames complexed with inhibitor a110
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: guab, ba_0008, bas0011, gbaa_0008. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (349 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4mz1
Crystal structure of the inosine 5'-monophosphate dehydrogen a internal deletion of cbs domain from campylobacter jejuni with inhibitor compound p12
Source: Campylobacter jejuni subsp. Jejuni. Organism_taxid: 192222. Strain: nctc 11168. Gene: guab, cj1058c. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C (354 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4mz8
Crystal structure of the inosine 5'-monophosphate dehydrogen an internal deletion of cbs domain from campylobacter jejun complexed with inhibitor compound c91
Source: Campylobacter jejuni subsp. Jejuni. Organism_taxid: 192222. Strain: nctc 11168. Gene: guab, cj1058c. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (353 residues)
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4q32
Crystal structure of inosine 5'-monophosphate dehydrogenase clostridium perfringens complexed with imp and c91
Source: Clostridium perfringens. Organism_taxid: 195103. Strain: atcc 13124 / nctc 8237 / type a. Gene: cpf_2558, guab. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (337 residues)
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4q33
Crystal structure of inosine 5'-monophosphate dehydrogenase clostridium perfringens complexed with imp and a110
Source: Clostridium perfringens. Organism_taxid: 195103. Strain: atcc 13124 / nctc 8237 / type a. Gene: cpf_2558, guab. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H (344 residues)
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
4qq3
Inosine 5'-monophosphate dehydrogenase from vibrio cholerae, mutant, in complex with xmp
Source: Vibrio cholerae o1 biovar el tor str. Organism_taxid: 243277. Strain: atcc 39315 / el tor inaba n16961. Gene: guab, vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (302 residues)
Bound ligand:   Het Group XMP corresponds to enzyme product xanthosine