_EC 1.1.1.169 2-dehydropantoate 2-reductase. 14 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,621 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,860 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,668 PDB entries]
EC 1.1.1.169 2-dehydropantoate 2-reductase. [14 PDB entries]    
1ks9

Pathway: Coenzyme A Biosynthesis (early stages)
Reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + Nadph.
 


(R)-pantoate
+
NADP(+)
=
2-dehydropantoate
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Ketopantoate reductase. Ketopantoic acid reductase. Kpa reductase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.1.1.1.169

  PDB code Protein
1ks9
Ketopantoate reductase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Gene: pane (apba). Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (291 residues) CATH domains: 3.40.50.720 1.10.1040.10
1yjq
Crystal structure of ketopantoate reductase in complex with NADP+
Source: Escherichia coli. Organism_taxid: 562. Gene: pane. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (293 residues) CATH domains: 3.40.50.720 1.10.1040.10
Bound ligands:   Het Group MPD is 50.00% similar to enzyme reactant (R)-pantoate
  Het Group NAP corresponds to enzyme reactant NADP(+)
1yon
Escherichia coli ketopantoate reductase in complex with 2- monophosphoadenosine-5'-diphosphate
Source: Escherichia coli. Organism_taxid: 562. Gene: pane. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (292 residues) CATH domains: 3.40.50.720 1.10.1040.10
Bound ligand:   Het Group APX is 79.00% similar to enzyme reactant NADP(+)
2ew2
Crystal structure of the putative 2-dehydropantoate 2-reduct enterococcus faecalis
Source: Enterococcus faecalis. Organism_taxid: 226185. Strain: v583. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (313 residues) CATH domains: 3.40.50.720 1.10.1040.10
2ofp
Crystal structure of escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: pane, apba. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (293 residues) CATH domains: 3.40.50.720 1.10.1040.10
Bound ligands:   Het Group PAF corresponds to enzyme reactant (R)-pantoate
  Het Group NAP corresponds to enzyme reactant NADP(+)
2qyt
Crystal structure of 2-dehydropantoate 2-reductase from porp gingivalis w83
Source: Porphyromonas gingivalis. Organism_taxid: 242619. Strain: w83. Atcc: baa-308. Gene: pane, pg_2205. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (287 residues) CATH domains: 3.40.50.720 1.10.1040.10
Bound ligand:   Het Group EDO is 40.00% similar to enzyme reactant (R)-pantoate
3ego
Crystal structure of probable 2-dehydropantoate 2-reductase pane from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: pane, apba, ylbq, bsu15110. Expressed in: escherichia coli.
Chains: A, B (292 residues) CATH domains: 3.40.50.720 1.10.1040.10
3g17
Structure of putative 2-dehydropantoate 2-reductase from staphylococcus aureus
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 158878. Strain: mu50. Gene: sav2600. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (286 residues) CATH domains: 3.40.50.720 1.10.1040.10
3hn2
Crystal structure of 2-dehydropantoate 2-reductase from geob metallireducens gs-15
Source: Geobacter metallireducens. Organism_taxid: 269799. Strain: gs-15. Atcc: 53774. Gene: gmet_2643. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (302 residues) CATH domains: 3.40.50.720 1.10.1040.10
3hwr
Crystal structure of pane/apba family ketopantoate reductase (yp_299159.1) from ralstonia eutropha jmp134 at 2.15 a reso
Source: Ralstonia eutropha. Organism_taxid: 264198. Strain: jmp134. Gene: reut_b4967, yp_299159.1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (299 residues) CATH domains: 3.40.50.720 1.10.1040.10
Bound ligands:   Het Group MRD is 50.00% similar to enzyme reactant (R)-pantoate
  Het Group NDP corresponds to enzyme reactant NADP(+)
3i83
Crystal structure of 2-dehydropantoate 2-reductase from meth capsulatus
Source: Methylococcus capsulatus. Organism_taxid: 414. Gene: mca2523, pane. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (310 residues) CATH domains: 3.40.50.720 1.10.1040.10
Bound ligand:   Het Group ACY is 40.00% similar to enzyme reactant (R)-pantoate
3wfi
The crystal structure of d-mandelate dehydrogenase
Source: Enterococcus faecium. Organism_taxid: 1352. Strain: iam10071. Gene: plg1-0150. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (311 residues)
3wfj
The complex structure of d-mandelate dehydrogenase with nadh
Source: Enterococcus faecium. Organism_taxid: 1352. Strain: iam10071. Gene: plg1-0150. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (299 residues)
Bound ligand:   Het Group NAD is 91.67% similar to enzyme reactant NADP(+)
4ol9
Crystal structure of putative 2-dehydropantoate 2-reductase mycobacterium tuberculosis complexed with NADP and oxamate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: rv2573, mt2649, mtcy227.28c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (297 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group OXM is 45.45% similar to enzyme reactant (R)-pantoate
  Het Group NAP corresponds to enzyme reactant NADP(+)