_EC 1.1.1.146 11-beta-hydroxysteroid dehydrogenase. 41 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,840 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,886 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,695 PDB entries]
EC 1.1.1.146 11-beta-hydroxysteroid dehydrogenase. [41 PDB entries]    
1xse

Reaction: An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + Nadph.
 

11-beta-hydroxysteroid
+
NADP(+)
= 11-oxosteroid
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Corticosteroid 11-beta-dehydrogenase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 41 PDB entries in enzyme class E.C.1.1.1.146

  PDB code Protein
1xse
Crystal structure of guinea pig 11beta-hydroxysteroid dehydr type 1
Source: Cavia porcellus. Domestic guinea pig. Organism_taxid: 10141. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (274 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1xu7
Crystal structure of the interface open conformation of tetr 11b-hsd1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell: dh10b-tir.
Chains: A, B, C, D (263 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1xu9
Crystal structure of the interface closed conformation of 11b-hydroxysteroid dehydrogenase isozyme 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (269 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1y5m
The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: hsd11b1, hsd11. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1y5r
The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: hsd11b1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
2bel
Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (243 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2ilt
Human 11-beta-hydroxysteroid dehydrogenase (hsd1) with NADP adamantane sulfone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1
Chain: A (275 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2irw
Human 11-beta-hydroxysteroid dehydrogenase (hsd1) with NADP adamantane ether inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1
Chains: A, B, C, D, E, F, G, H (264 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2rbe
The discovery of 2-anilinothiazolones as 11beta-hsd1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (259 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP is 97.00% similar to enzyme reactant NADP(+)
3byz
2-amino-1,3-thiazol-4(5h)-ones as potent and selective 11- hydroxysteroid dehydrogenase type 1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (258 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3bzu
Crystal structure of human 11-beta-hydroxysteroid dehydrogen in complex with NADP and thiazolone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (263 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3ch6
Crystal structure of 11beta-hsd1 double mutant (l262r, f278e) complexed with (3,3-dimethylpiperidin-1-yl)(6-(3- fluoro-4-methylphenyl)pyridin-2-yl)methanone
Source: Homo sapiens. Human. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli.
Chains: A, B, D, E (264 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3czr
Crystal structure of human 11-beta-hydroxysteroid dehydrogenase (hsd1) in complex with arylsulfonylpiperazine inhibitor
Source: Homo sapiens. Human. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli.
Chains: A, B (265 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3d3e
Crystal structure of human 11-beta-hydroxysteroid dehydrogenase (hsd1) in complex with benzamide inhibitor
Source: Homo sapiens. Human. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli.
Chains: A, B, C, D (262 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3d4n
Crystal structure of human 11-beta-hydroxysteroid dehydrogenase (hsd1) in complex with sulfonamide inhibitor
Source: Homo sapiens. Human. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli.
Chains: A, B, C, D (261 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3d5q
Crystal structure of 11b-hsd1 in complex with triazole inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli.
Chains: A, B, C, D (264 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3dwf
Crystal structure of the guinea pig 11beta-hydroxysteroid dehydrogenase type 1 mutant f278e
Source: Cavia porcellus. Guinea pig. Organism_taxid: 10141. Gene: hsd11b1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (271 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3ey4
Further studies with the 2-amino-1,3-thiazol-4(5h)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-hsd1) inhibitors: reducing pregnane x receptor (pxr) activity and exploring activity in a monkey pharmacodynamic model
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 516
Chains: A, B, C, D (259 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3fco
Crystal structure of 11beta-hydroxysteroid dehydrogenase 1 (11b-hsd1) in complex with benzamide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3frj
Crystal structure of 11b-hydroxysteroid dehydrogenase-1 (11b-hsd1) in complex with piperidyl benzamide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3g49
N-(pyridin-2-yl) arylsulfonamide inhibitors of 11b-hydroxyst dehydrogenase type 1: discovery of pf-915275
Source: Cavia porcellus. Guinea pig. Organism_taxid: 10141. Gene: hsd11b1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (263 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3gmd
Structure-based design of 7-azaindole-pyrrolidines as inhibi 11beta-hydroxysteroid-dehydrogenase type i
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: hsd11, hsd11b1, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: humanized mouse 11-beta hsd
Chains: A, C, D, E, F, G, H (264 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3h6k
Crystal structure of human 11-beta-hydroxysteroid- dehydrogenase bound to an ortho-chlro-sulfonyl-piperazine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11, hsd11b1, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (260 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3hfg
Crystal structure of human 11-beta-hydroxysteroid- dehydrogenase bound to an sulfonyl-piperazine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (258 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3lz6
Guinea pig 11beta hydroxysteroid dehydrogenase with pf-87742
Source: Cavia porcellus. Guinea pig. Organism_taxid: 10141. Gene: hsd11b1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (263 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3oq1
Crystal structure of 11beta-hydroxysteroid dehydrogenase-1 ( in complex with diarylsulfone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (261 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3pdj
Crystal structure of human 11-beta-hydroxysteroid dehydrogen (11b-hsd1) in complex with 4,4-disubstituted cyclohexylbenz inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11, hsd11b1, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (272 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3qqp
Crystal structure of 11beta-hydroxysteroid dehydrogenase 1 ( in complex with urea inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11, hsd11b1, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (270 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
3tfq
Crystal structure of 11b-hsd1 double mutant (l262r, f278e) c with 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3, 1h-pyrano[3,4-c]pyridine-5-carbonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (262 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4bb5
Free-wilson and structural approaches to co-optimising human rodent isoform potency for 11b-hydroxysteroid dehydrogenase 11b-hsd1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (263 residues) CATH domain: 3.40.50.720
4bb6
Free-wilson and structural approaches to co-optimising human rodent isoform potency for 11b-hydroxysteroid dehydrogenase 11b-hsd1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (266 residues) CATH domain: 3.40.50.720
4c7k
11b-hydroxysteroid dehydrogenase type i in complex with inhi
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (258 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4hfr
Human 11beta-hydroxysteroid dehydrogenase type 1 in complex orally bioavailable acidic inhibitor azd4017.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (255 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4hx5
Crystal structure of 11 beta-hsd1 in complex with sar184841
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (261 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4iju
Crystal structure of 11b-hsd1 double mutant (l262r, f278e) i with (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]py yl]bicyclo[2.2.1]heptan-1-ol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (266 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4ijv
Crystal structure of 11b-hsd1 double mutant (l262r, f278e) i with 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[ 4]triazolo[4,3-a]pyridine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (266 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4ijw
Crystal structure of 11b-hsd1 double mutant (l262r, f278e) i with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2, 4]triazolo[4,3-a]pyridine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (263 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4k1l
4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of hsd1 inhibitors for the treatment of diabetes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (263 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4k26
4,4-dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of inhibitors for the treatment of diabetes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: hsd11b1, hsd11. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (265 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4nmh
11-beta-hsd1 in complex with a 3,3-di-methyl-azetidin-2-one
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: hsd11b1, hsd11. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (265 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4p38
Human 11beta-hydroxysteroid dehydrogenase type 1 in complex azd8329
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (265 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)