_EC 1.1.1.14 L-iditol 2-dehydrogenase. 8 PDB entries  
EC 1.-.-.- Oxidoreductases. [9,401 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [2,051 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,833 PDB entries]
EC 1.1.1.14 L-iditol 2-dehydrogenase. [8 PDB entries]    
1k2w

Reaction: L-iditol + NAD(+) = L-sorbose + Nadh.
 


L-iditol
+
NAD(+)
=
L-sorbose
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glucitol dehydrogenase. Polyol dehydrogenase. Sorbitol dehydrogenase.
Comments: This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD(+) and can not use NADP(+).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.1.1.1.14

  PDB code Protein
1k2w
Crystal structure of sorbitol dehydrogenase from r. Sphaeroides
Source: Rhodobacter sphaeroides. Organism_taxid: 1063. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (256 residues) CATH domain: 3.40.50.720
1pl6
Human sdh/nadh/inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (356 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1pl7
Human sorbitol dehydrogenase (apo)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (356 residues) CATH domains: 3.90.180.10 3.40.50.720
1pl8
Human sdh/NAD+ complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (356 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1uzo
Crystal structure of sorbitol dehydrogenase from r.Sphaeroides
Source: Rhodobacter sphaeroides. Expressed in: escherichia coli
Chain: A (256 residues)
3qe3
Sheep liver sorbitol dehydrogenase
Source: Ovis aries. Sheep. Organism_taxid: 9940. Organ: liver. Gene: sord. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (351 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant L-iditol
4e6p
Crystal structure of a probable sorbitol dehydrogenase (targ 012078) from sinorhizobium meliloti 1021
Source: Sinorhizobium meliloti. Organism_taxid: 266834. Strain: 1021. Gene: smos, r02441, smc01500. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (256 residues) CATH domain: 3.40.50.720
4oh1
Crystal structure of a putative zinc-binding dehydrogenase ( clostridium scindens atcc 35704 at 2.00 a resolution
Source: Clostridium scindens. Organism_taxid: 411468. Strain: atcc 35704. Gene: closci_00901, gutb, zp_02430688. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (351 residues) CATH domains: Unassigned Unassigned