_EC 1.1.1.132 GDP-mannose 6-dehydrogenase. 3 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,685 PDB entries]
EC 1.1.1.132 GDP-mannose 6-dehydrogenase. [3 PDB entries]    
1mfz

Reaction: GDP-D-mannose + 2 NAD(+) + H(2)O = GDP-D-mannuronate + 2 Nadh.
 


GDP-D-mannose
+
2 × NAD(+)
+ H(2)O
=
GDP-D-mannuronate
+
2 × NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Also uses the corresponding deoxynucleoside diphosphate derivative as a substrate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.1.1.1.132

  PDB code Protein
1mfz
Partially refined 2.8 a crystal structure of gdp-mannose dehydrogenase from p. Aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algd. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (436 residues) CATH domains: 3.40.50.720 1.20.5.170 3.40.50.720
Bound ligand:   Het Group GDX corresponds to enzyme product GDP-D-mannuronate
1muu
2.0 a crystal structure of gdp-mannose dehydrogenase
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algd. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (436 residues) CATH domains: 3.40.50.720 1.20.5.170 3.40.50.720
Bound ligands:   Het Group NAD is 79.00% similar to enzyme reactant NAD(+)
  Het Group GDX corresponds to enzyme product GDP-D-mannuronate
1mv8
1.55 a crystal structure of a ternary complex of gdp-mannose dehydrogenase from psuedomonas aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algd. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (436 residues) CATH domains: 3.40.50.720 1.20.5.170 3.40.50.720
Bound ligands:   Het Group NAD is 79.55% similar to enzyme reactant NAD(+)
  Het Group GDX corresponds to enzyme product GDP-D-mannuronate