_EC 1.1.1.1 Alcohol dehydrogenase. 114 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,609 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,856 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,664 PDB entries]
EC 1.1.1.1 Alcohol dehydrogenase. [114 PDB entries]    
1a4u

Reaction: (1) An alcohol + NAD(+) = an aldehyde or ketone + Nadh. (2) A secondary alcohol + NAD(+) = a ketone + nadh.
 


alcohol
+
NAD(+)
= aldehyde or ketone
+
NADH

secondary alcohol
+
NAD(+)
=
ketone
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Aldehyde reductase.
Cofactor(s): Zinc or iron.
Comments: Acts on primary or secondary alcohols or hemi-acetalss with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 114 PDB entries in enzyme class E.C.1.1.1.1

  PDB code Protein
1a4u
Alcohol dehydrogenase from drosophila lebanonensis
Source: Scaptodrosophila lebanonensis. Organism_taxid: 7225
Chains: A, B (254 residues) CATH domain: 3.40.50.720
1a71
Ternary complex of an active site double mutant of horse liver alcohol dehydrogenase, phe93=>trp, val203=>ala with NAD and trifluoroethanol
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Gene: ladh f93w v203a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1a72
An active-site double mutant (phe93->trp, val203->ala) of ho alcohol dehydrogenase in complex with the isosteric NAD ana
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Gene: f93w v203aladh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group PAD is 66.04% similar to enzyme reactant NAD(+)
1adb
Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes
Source: Equus caballus. Horse. Organism_taxid: 9796
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group CND is 66.00% similar to enzyme reactant NAD(+)
1adc
Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group PAD is 66.00% similar to enzyme reactant NAD(+)
1adf
Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide adenine dinucleotide (tad), the active anabolite of the antitumor agent tiazofurin
Source: Equus caballus. Horse. Organism_taxid: 9796
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
1adg
Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide adenine dinucleotide (tad), the active anabolite of the antitumor agent tiazofurin
Source: Equus caballus. Horse. Organism_taxid: 9796
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
1agn
X-ray structure of human sigma alcohol dehydrogenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: stomach. Gene: human sigma cdna (adh7). Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: purchased from boeringer mannheim (indianapolis, in)
Chains: A, B, C, D (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1axe
Crystal structure of the active-site mutant phe93->trp of horse liver alcohol dehydrogenase in complex with NAD and inhibitor trifluoroethanol
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Gene: ladh cdna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1axg
Crystal structure of the val203->ala mutant of liver alcohol dehydrogenase complexed with cofactor NAD and inhibitor trifluoroethanol solved to 2.5 angstrom resolution
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Gene: ladh cdna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1b14
Alcohol dehydrogenase from drosophila lebanonensis binary co NAD+
Source: Scaptodrosophila lebanonensis. Organism_taxid: 7225
Chains: A, B (254 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1b15
Alcohol dehydrogenase from drosophila lebanonensis ternary complex with NAD-acetone
Source: Scaptodrosophila lebanonensis. Organism_taxid: 7225
Chains: A, B (254 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAE is 91.00% similar to enzyme reactant NAD(+)
1b16
Alcohol dehydrogenase from drosophila lebanonensis ternary c with NAD-3-pentanone
Source: Scaptodrosophila lebanonensis. Organism_taxid: 7225
Chains: A, B (254 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAQ is 88.00% similar to enzyme reactant NAD(+)
1b2l
Alcohol dehydrogenase from drosophila lebanonensis: ternary with NAD-cyclohexanone
Source: Scaptodrosophila lebanonensis. Organism_taxid: 7225
Chain: A (254 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NDC is 86.27% similar to enzyme reactant NAD(+)
1bto
Horse liver alcohol dehydrogenase complexed to nadh and (1s, 3r)3-butylthiolane 1-oxide
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Other_details: commercial preparation of enzyme from horse liver. Cdna sequence m64864
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1cdo
Alcohol dehydrogenase (E.C.1.1.1.1) (ee isozyme) complexed w nicotinamide adenine dinucleotide (NAD), and zinc
Source: Gadus callarias. Baltic cod. Organism_taxid: 8053. Organ: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1d1s
Wild-type human sigma (class iv) alcohol dehydrogenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Pharmacia
Chains: A, B, C, D (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1d1t
Mutant of human sigma alcohol dehydrogenase with leucine at 141
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Pharmacia
Chains: A, B, C, D (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1dda
Homology model of adh gg with iso-ursodeoxycholic acid
Source: Homo sapiens. Human. Organ: liver
Chains: A, B (374 residues)
Bound ligand:   Het Group NAD corresponds to enzyme product NADH
1deh
Crystallization of human beta1 alcohol dehydrogenase (15 mg/ml) in 50 mm sodium phosphate (ph 7.5), 2.0 mm NAD+ and 1 mm 4-iodopyrazole at 25 oc, 13% (w/v) peg 8000
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Gene: human beta1 cdna. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: adh2 - standard convention is to denote the polymorphism with a 1 in superscript, i.E., Adh2==1==)
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1e3e
Mouse class ii alcohol dehydrogenase complex with nadh
Source: Mus musculus. House mouse. Organism_taxid: 10090. Organ: liver. Gene: adh-2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (376 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group NAI corresponds to enzyme reactant NAD(+)
1e3i
Mouse class ii alcohol dehydrogenase complex with nadh and i
Source: Mus musculus. House mouse. Organism_taxid: 10090. Organ: liver. Gene: adh-2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (376 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group NAI corresponds to enzyme reactant NAD(+)
1e3l
P47h mutant of mouse class ii alcohol dehydrogenase complex with nadh
Source: Mus musculus. House mouse. Organism_taxid: 10090. Organ: liver. Cellular_location: cytosolic. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (376 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1ee2
The structure of steroid-active alcohol dehydrogenase at 1.5 resolution
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1h2b
Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon aeropyrum pernix at 1.65a resolution
Source: Aeropyrum pernix. Organism_taxid: 56636. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (343 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAJ corresponds to enzyme reactant NAD(+)
1hdx
Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their functional differences
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1hdy
Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their functional differences
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1hdz
Three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their functional differences
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1het
Atomic x-ray structure of liver alcohol dehydrogenase containing a hydroxide adduct to nadh
Source: Equus caballus. Domestic horse. Organism_taxid: 9796. Organ: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1heu
Atomic x-ray structure of liver alcohol dehydrogenase containing cadmium and a hydroxide adduct to nadh
Source: Equus caballus. Domestic horse. Organism_taxid: 9796. Organ: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1hf3
Atomic x-ray structure of liver alcohol dehydrogenase containing cadmium and a hydroxide adduct to nadh
Source: Equus caballus. Domestic horse. Organism_taxid: 9796
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1hld
Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols
Source: Equus caballus. Horse. Organism_taxid: 9796
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1hso
Human alpha alcohol dehydrogenase (adh1a)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1hsz
Human beta-1 alcohol dehydrogenase (adh1b 1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh2 or adh1b 1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1ht0
Human gamma-2 alcohol dehydrogense
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh3 or adh1c 2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1htb
Crystallization of human beta3 alcohol dehydrogenase (10 mg/ml) in 100 mm sodium phosphate (ph 7.5), 7.5 mm NAD+ and 1 mm 4-iodopyrazole at 25 c
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Gene: human beta3 cdna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1j5r
Crystal structure of alcohol dehydrogenase (tm0920) from thermotoga maritima at 1.4 a resolution
Source: Thermotoga maritima. Bacteria. Gene: tm0920. Expressed in: escherichia coli.
Chains: A, B (359 residues) CATH domains: 3.40.50.1970 1.20.1090.10
Bound ligand:   Het Group NAP is 91.00% similar to enzyme reactant NAD(+)
1ju9
Horse liver alcohol dehydrogenase val292ser mutant
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Gene: m64864. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD is 61.00% similar to enzyme reactant NAD(+)
1jvb
Alcohol dehydrogenase from the archaeon sulfolobus solfataricus
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Gene: adh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (347 residues) CATH domains: 3.90.180.10 3.40.50.720
1lde
Horse liver alcohol dehydrogenase complexed to nadh and n-fo piperdine
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Other_details: commercial preparation of enzyme from horse cdna sequence m64864
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1ldy
Horse liver alcohol dehydrogenase complexed to nadh and cyclohexyl formamide (cxf)
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Other_details: commercial preparation of enzyme from horse liver. Cdna sequence m64864
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1m6h
Human glutathione-dependent formaldehyde dehydrogenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
1m6w
Binary complex of human glutathione-dependent formaldehyde dehydrogenase and 12-hydroxydodecanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
1ma0
Ternary complex of human glutathione-dependent formaldehyde dehydrogenase with NAD+ and dodecanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1mc5
Ternary complex of human glutathione-dependent formaldehyde dehydrogenase with s-(hydroxymethyl)glutathione and nadh
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1mg0
Horse liver alcohol dehydrogenase complexed with NAD+ and 2, 3-difluorobenzyl alcohol
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1mg5
Crystal structure of drosophila melanogaster alcohol dehydro complexed with nadh and acetate at 1.6 a
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Other_details: adh-slow allele
Chains: A, B (255 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group NAI corresponds to enzyme reactant NAD(+)
1mgo
Horse liver alcohol dehydrogenase phe93ala mutant
Source: Equus caballus. Horse. Organism_taxid: 9796. Gene: m64864. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1mp0
Binary complex of human glutathione-dependent formaldehyde dehydrogenase with NAD(h)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1n8k
Horse liver alcohol dehydrogenase val292thr mutant complexed to NAD+ and pyrazole
Source: Equus caballus. Horse. Organism_taxid: 9796. Gene: adhe m64864. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAJ corresponds to enzyme reactant NAD(+)
1n92
Horse liver alcohol dehydrogenase complexed with NAD+ and 4- iodopyrazole
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAJ corresponds to enzyme reactant NAD(+)
1nto
N249y mutant of alcohol dehydrogenase from the archaeon sulf solfataricus-monoclinic crystal form
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Gene: adh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, H (347 residues) CATH domains: 3.90.180.10 3.40.50.720
1nvg
N249y mutant of the alcohol dehydrogenase from the archaeon sulfolobus solfataricus-tetragonal crystal form
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Gene: adh or sso2536. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (347 residues) CATH domains: 3.90.180.10 3.40.50.720
1otq
Computer aided modeling of alcohol dehydrogenase class iii
Source: Mus musculus. Mouse
Chain: A (373 residues)
1p1r
Horse liver alcohol dehydrogenase complexed with nadh and r- n-1-methylhexylformamide
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAI corresponds to enzyme reactant NAD(+)
1qlh
Horse liver alcohol dehydrogenase complexed to NAD double mutant of gly 293 ala and pro 295 thr
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: e.Coli expressed mutant protein
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD is 97.00% similar to enzyme reactant NAD(+)
1qlj
Horse liver alcohol dehydrogenase apo enzyme double mutant of gly 293 ala and pro 295 thr
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: e.Coli expressed mutant protein
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
1qv6
Horse liver alcohol dehydrogenase his51gln/lys228arg mutant complexed with NAD+ and 2,4-difluorobenzyl alcohol
Source: Equus caballus. Horse. Organism_taxid: 9796. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1qv7
Horse liver alcohol dehydrogenase his51gln/lys228arg mutant complexed with NAD+ and 2,3-difluorobenzyl alcohol
Source: Equus caballus. Horse. Organism_taxid: 9796. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1r37
Alcohol dehydrogenase from sulfolobus solfataricus complexed with NAD(h) and 2-ethoxyethanol
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Gene: adh or sso2536. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (347 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1rjw
Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Strain: lld-r. Gene: adh-ht. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (339 residues) CATH domains: 3.90.180.10 3.40.50.720
1sby
Alcohol dehydrogenase from drosophila lebanonensis complexed with NAD+ and 2,2,2-trifluoroethanol at 1.1 a resolution
Source: Scaptodrosophila lebanonensis. Organism_taxid: 7225
Chains: A, B (254 residues) CATH domain: 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1teh
Structure of human liver chichi alcohol dehydrogenase (a glu dependent formaldehyde dehydrogenase)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1u3t
Crystal structure of human alcohol dehydrogenase alpha- alpha isoform complexed with n-cyclopentyl-n- cyclobutylformamide determined to 2.5 angstrom resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1u3u
Crystal structure of human alcohol dehydrogenase beta-1- beta-1 isoform complexed with n-benzylformamide determined to 1.6 angstrom resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1u3v
Crystal structure of human alcohol dehydrogenase beta-1- beta-1 isoform complexed with n-heptylformamide determined to 1.65 angstrom resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1u3w
Crystal structure of human alcohol dehydrogenase gamma-2- gamma-2 isoform complexed with n-1-methylheptylformamide determined to 1.45 angstrom resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh1c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1ye3
Horse liver alcohol dehydrogenase apoenzyme
Source: Equus caballus. Horse. Organism_taxid: 9796. Other_details: liver
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
2eer
Structural study of project id st2577 from sulfolobus tokoda
Source: Sulfolobus tokodaii. Organism_taxid: 273063. Strain: 7. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (346 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2fze
Crystal structure of the binary complex of human glutathione-dependent formaldehyde dehydrogenase with adp- ribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5, adhx, fdh. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group APR is 77.00% similar to enzyme reactant NAD(+)
2fzw
Structure of the binary complex of the e67l mutant of human glutathione-dependent formaldehyde dehydrogenase with NAD(h)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5, adhx, fdh. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (373 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2h6e
Crystal structure of the d-arabinose dehydrogenase from sulf solfataricus
Source: Sulfolobus solfataricus. Organism_taxid: 273057. Strain: p2. Gene: adh-4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (323 residues) CATH domains: 3.90.180.10 3.40.50.720
2hcy
Yeast alcohol dehydrogenase i, saccharomyces cerevisiae ferm enzyme
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: laboratory strain. Gene: adh1, adc1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B, C, D (347 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group 8ID is 97.78% similar to enzyme reactant NAD(+)
2jhf
Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase
Source: Equus caballus. Horse. Organism_taxid: 9796. Variant: horse liver. Organ: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2jhg
Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase
Source: Equus caballus. Horse. Organism_taxid: 9796. Variant: horse liver. Organ: liver. Other_details: horse liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2ohx
Refined crystal structure of liver alcohol dehydrogenase- nadh complex at 1.8 angstroms resolution
Source: Equus caballus. Horse. Organism_taxid: 9796
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2oxi
Refined crystal structure of cu-substituted alcohol dehydrogenase at 2.1 angstroms resolution
Source: Equus caballus. Horse. Organism_taxid: 9796
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
2xaa
Alcohol dehydrogenase adh-'a' from rhodococcus ruber dsm 44541 at ph 8.5 in complex with NAD and butane-1,4-diol
Source: Rhodococcus ruber. Organism_taxid: 1830. Strain: dsm 44541. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: dsm
Chains: A, B, C, D (333 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
3bto
Horse liver alcohol dehydrogenase complexed to nadh and (1s, 3s)3-butylthiolane 1-oxide
Source: Equus caballus. Horse. Organism_taxid: 9796. Organ: liver. Cellular_location: cytoplasm. Other_details: commercial preparation of enzyme from horse liver. Cdna sequence m64864
Chains: A, B, C, D (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
3cos
Crystal structure of human class ii alcohol dehydrogenase (a complex with NAD and zn
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (379 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
3hud
The structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
3i4c
Crystal structure of sulfolobus solfataricus adh(ssadh) double mutant (w95l,n249y)
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Gene: adh, sso2536. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, H (340 residues) CATH domains: 3.90.180.10 3.40.50.720
3jv7
Structure of adh-a from rhodococcus ruber
Source: Rhodococcus ruber. Organism_taxid: 1830. Strain: dsm 44541. Gene: adh-a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, C, D ( residues)
3oq6
Horse liver alcohol dehydrogenase a317c mutant complexed wit 2,3,4,5,6-pentafluorobenzyl alcohol
Source: Equus caballus. Domestic horse,equine. Organism_taxid: 9796. Gene: adh e. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAJ corresponds to enzyme reactant NAD(+)
3owo
Structures of iron-dependent alcohol dehydrogenase 2 from zy mobilis zm4 with and without NAD cofactor
Source: Zymomonas mobilis. Organism_taxid: 542. Strain: zm4. Gene: adhb, zmo1596. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (382 residues) CATH domains: 3.40.50.1970 1.20.1090.10
3ox4
Structures of iron-dependent alcohol dehydrogenase 2 from zy mobilis zm4 complexed with NAD cofactor
Source: Zymomonas mobilis. Organism_taxid: 542. Strain: zm4. Gene: adhb, zmo1596. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (382 residues) CATH domains: 3.40.50.1970 1.20.1090.10
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
3pii
Crystal structure of mutant of ht- alcohol dehydrogenase wit substrate analogue butyramide
Source: Geobacillus stearothermophilus. Bacillus thermoliquefaciens. Organism_taxid: 1422. Gene: adh-ht. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C, B, D (337 residues) CATH domains: 3.90.180.10 3.40.50.720
3qj5
S-nitrosoglutathione reductase (gsnor) in complex with n6022
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adh5, adhx, fdh. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (372 residues) CATH domains: 3.90.180.10 3.40.50.720
3rj5
Structure of alcohol dehydrogenase from drosophila lebanones mutant complexed with NAD+
Source: Scaptodrosophila lebanonensis. Fruit fly. Organism_taxid: 7225. Gene: adh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (254 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
3rj9
Structure of alcohol dehydrogenase from drosophila lebanones mutant complexed with NAD+
Source: Scaptodrosophila lebanonensis. Fruit fly. Organism_taxid: 7225. Gene: adh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (254 residues) CATH domain: 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
3uko
Crystal structure of s-nitrosoglutathione reductase from ara thaliana, complex with nadh
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: adh2, adhiii, fdh1, at5g43940, mrh10.4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (378 residues) CATH domains: 3.90.180.10 3.40.50.720
3uog
Crystal structure of putative alcohol dehydrogenase from sin meliloti 1021
Source: Sinorhizobium meliloti 1021. Organism_taxid: 266834. Strain: 1021. Gene: r02449, smc01816. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (341 residues) CATH domains: 3.90.180.10 3.40.50.720
3wle
Crystal structure of (r)-carbonyl reductase from candida par in complex with NAD
Source: Candida parapsilosis. Yeast. Organism_taxid: 5480. Strain: cctcc m203011. Gene: cpradh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (335 residues)
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
3wlf
Crystal structure of (r)-carbonyl reductase from candida par in complex with (r)-1-phenyl-1,2-ethanediol
Source: Candida parapsilosis. Yeast. Organism_taxid: 5480. Strain: cctcc m203011. Gene: cpradh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (335 residues)
3wnq
Crystal structure of (r)-carbonyl reductase h49a mutant from parapsilosis in complex with 2-hydroxyacetophenone
Source: Candida parapsilosis. Yeast. Organism_taxid: 5480. Strain: cctcc m203011. Gene: rcr, cpradh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (335 residues)
4dl9
Crystal structure of s-nitrosoglutathione reductase from tom (solanum lycopersicum) in complex with NAD+
Source: Solanum lycopersicum. Tomato. Organism_taxid: 4081. Strain: cv. Amateur. Gene: adh3, gsnor. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (379 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
4dla
Crystal structure of s-nitrosoglutathione reductase apoenzym tomato (solanum lycopersicum)
Source: Solanum lycopersicum. Tomato. Organism_taxid: 4081. Strain: cv. Amateur. Gene: adh3, gsnor. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (379 residues) CATH domains: 3.90.180.10 3.40.50.720
4dlb
Structure of s-nitrosoglutathione reductase from tomato (sol lycopersicum) crystallized in presence of nadh and glutathi
Source: Solanum lycopersicum. Tomato. Organism_taxid: 4081. Strain: cv. Amateur. Gene: adh3, gsnor. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (379 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
4dwv
Horse alcohol dehydrogenase complexed with NAD+ and 2,3,4,5, pentafluorobenzyl alcohol
Source: Equus caballus. Domestic horse,equine. Organism_taxid: 9796. Organ: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAJ corresponds to enzyme reactant NAD(+)
  Het Group NAJ corresponds to enzyme reactant NAD(+)
4dxh
Horse liver alcohol dehydrogenase complexed with NAD+ and 2, trifluoroethanol
Source: Equus caballus. Domestic horse,equine. Organism_taxid: 9796. Strain: domestic horse. Organ: liver. Other_details: liver
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAJ corresponds to enzyme reactant NAD(+)
  Het Group NAJ corresponds to enzyme reactant NAD(+)
4eex
Crystal structure of lactococcus lactis alcohol dehydrogenas
Source: Lactococcus lactis subsp. Lactis. Organism_taxid: 684738. Strain: kf147. Gene: adha, llkf_1981. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (339 residues) CATH domains: 3.90.180.10 3.40.50.720
4eez
Crystal structure of lactococcus lactis alcohol dehydrogenas re1
Source: Lactococcus lactis subsp. Lactis. Organism_taxid: 684738. Strain: kf147. Gene: adha, llkf_1981. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (339 residues) CATH domains: 3.90.180.10 3.40.50.720
4gkv
Structure of escherichia coli adhp (ethanol-inducible dehydr with bound NAD
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12 (substrain mg1655). Gene: adhp, yddn, b1478, jw1474. Expressed in: escherichia coli. Expression_system_taxid: 511693. Organism_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D (336 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
4gl4
Crystal structure of oxidized s-nitrosoglutathione reductase arabidopsis thalina, complex with nadh
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: adh2, adhiii, fdh1, at5g43940, mrh10.4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (378 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group NAI corresponds to enzyme reactant NAD(+)
4j6f
Crystal structure of putative alcohol dehydrogenase from sin meliloti 1021, nysgrc-target 012230
Source: Sinorhizobium meliloti. Ensifer meliloti. Organism_taxid: 266834. Strain: 1021. Gene: cac48808.1, sm_b20422. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (362 residues) CATH domains: 3.90.180.10 3.40.50.720
4jji
Crystal structure of s-nitrosoglutathione reductase from ara thalina, complex with NAD+
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: adh2, adhiii, fdh1, at5g43940, mrh10.4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (378 residues) CATH domains: 3.90.180.10 3.40.50.720
4l0q
Crystal structure of s-nitrosoglutathione reductase from ara thaliana, c370a/c373a double mutant
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: adh2, adhiii, fdh1, at5g43940, mrh10.4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (378 residues) CATH domains: 3.90.180.10 3.40.50.720
4nfh
V207a horse liver alcohol dehydrogenase e complexed with NAD 4,5,6-pentafluorobenzyl alcohol
Source: Equus caballus. Domestic horse,equine. Organism_taxid: 9796. Strain: domestic. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAJ corresponds to enzyme reactant NAD(+)
  Het Group NAJ corresponds to enzyme reactant NAD(+)
4nfs
V203a horse liver alcohol dehydrogenase e complexed with NAD 2-trifluoroethanol
Source: Equus caballus. Domestic horse,equine. Organism_taxid: 9796. Strain: domestic horse. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAJ corresponds to enzyme reactant NAD(+)
  Het Group NAJ corresponds to enzyme reactant NAD(+)
4ng5
V203a horse liver alcohol dehydrogenase e complexed with NAD 4,5,6-pentafluorobenzyl alcohol
Source: Equus caballus. Domestic horse,equine. Organism_taxid: 9796. Strain: domestic horse. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligands:   Het Group NAJ corresponds to enzyme reactant NAD(+)
  Het Group NAJ corresponds to enzyme reactant NAD(+)
5adh
Interdomain motion in liver alcohol dehydrogenase. Structura energetic analysis of the hinge bending mode
Source: Equus caballus. Horse. Organism_taxid: 9796
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group APR is 77.78% similar to enzyme reactant NAD(+)
6adh
Structure of triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 angstroms resolution
Source: Equus caballus. Horse. Organism_taxid: 9796
Chains: A, B (374 residues) CATH domains: 3.90.180.10 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
7adh
Three-dimensional structure of isonicotinimidylated liver alcohol dehydrogenase
Source: Equus caballus. Horse. Organism_taxid: 9796
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720
8adh
Interdomain motion in liver alcohol dehydrogenase. Structura energetic analysis of the hinge bending mode
Source: Equus caballus. Horse. Organism_taxid: 9796
Chain: A (374 residues) CATH domains: 3.90.180.10 3.40.50.720