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Index of protein targets for approved drugs and nutraceuticals

The alphabetical index below lists the proteins defined in DrugBank as the targets of approved drugs and nutraceuticals.

Names shown in purple are human proteins.

Columns: drug; biotech drug; nutraceutical; T   no. of target structures in the PDB; TD   no. of target-drug structures.

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D

UniProt accession and id Protein name T TD
P21728 DRD1_HUMAN D(1A) dopamine receptor 47 - - 1 -
P21918 DRD5_HUMAN D(1B) dopamine receptor 18 - - - -
P14416 DRD2_HUMAN D(2) dopamine receptor 66 - - 8 -
P35462 DRD3_HUMAN D(3) dopamine receptor 28 - - 1 -
P21917 DRD4_HUMAN D(4) dopamine receptor 24 - - - -
O43175 SERA_HUMAN D-3-phosphoglycerate dehydrogenase - - 1 1 -
D-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycan 1 1 - - -
P0A6J8 DDLA_ECOLI D-alanine--D-alanine ligase A 1 - - - -
P15555 DAC_STRSR D-alanyl-D-alanine carboxypeptidase 1 - - 16 -
P08506 DACC_ECOLI D-alanyl-D-alanine carboxypeptidase dacC 5 - - 4 -
P72161 PBP5_PSEAE D-alanyl-D-alanine endopeptidase 1 - - - -
Q02338 BDH_HUMAN D-beta-hydroxybutyrate dehydrogenase, mitochondrial - - 1 - -
P06149 DLD_ECOLI D-lactate dehydrogenase 1 - - 1 -
Q9NYX4 CALY_HUMAN D1 dopamine receptor-interacting protein calcyon 3 - - - -
DNA 75 1 4 - -
P26358 DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 4 - - 3 -
P43700 GYRA_HAEIN DNA gyrase subunit A 8 - - - -
P72524 GYRA_STRPN DNA gyrase subunit A (GYRA_STRPN) 1 - - - -
P43700 GYRA_HAEIN DNA gyrase subunit A (GYRA_HAEIN) 7 - - - -
P72524 GYRA_STRPN DNA gyrase subunit A (GYRA_STRPN) 1 - - - -
P0A4L9 GYRB_STRPN DNA gyrase subunit B 1 - - - -
P0AES6 GYRB_ECOLI DNA gyrase subunit B (GYRB_ECOLI) 1 - - 7 -
P0A0K8 GYRB_STAAU DNA gyrase subunit B (GYRB_STAAU) 1 - - 8 1
P18858 DNLI1_HUMAN DNA ligase 1 1 - - 1 -
P49916 DNLI3_HUMAN DNA ligase 3 1 - - 9 -
P04293 DPOL_HHV11 DNA polymerase 1 - - - -
P09252 DPOL_VZVD DNA polymerase (DPOL_VZVD) 1 - - - -
P04293 DPOL_HHV11 DNA polymerase (DPOL_HHV11) 1 - - - -
P08546 DPOL_HCMVA DNA polymerase (DPOL_HCMVA) 1 - - 1 -
P03198 DPOL_EBVB9 DNA polymerase (DPOL_EBVB9) 1 - - 1 -
P04293 DPOL_HHV11 DNA polymerase (DPOL_HHV11) 2 - - - -
P08546 DPOL_HCMVA DNA polymerase (DPOL_HCMVA) 1 - - 1 -
P04293 DPOL_HHV11 DNA polymerase (DPOL_HHV11) 2 - - - -
P09252 DPOL_VZVD DNA polymerase (DPOL_VZVD) 1 - - - -
P00582 DPO1_ECOLI DNA polymerase I 1 - - 14 -
P09884 DPOLA_HUMAN DNA polymerase alpha catalytic subunit 4 - - 3 -
P06746 DPOLB_HUMAN DNA polymerase beta 1 - - 188 -
Q07864 DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A 1 - - - -
P56282 DPOE2_HUMAN DNA polymerase epsilon subunit 2 1 - - 1 -
Q9NRF9 DPOE3_HUMAN DNA polymerase epsilon subunit 3 1 - - - -
Q9NR33 DPOE4_HUMAN DNA polymerase epsilon subunit 4 1 - - - -
Q14181 DPOA2_HUMAN DNA polymerase subunit alpha B 1 - - 2 -
P11387 TOP1_HUMAN DNA topoisomerase 1 4 - - 15 1
P11388 TOP2A_HUMAN DNA topoisomerase 2-alpha 23 - - 4 -
Q02880 TOP2B_HUMAN DNA topoisomerase 2-beta 3 - - 5 1
P43702 PARC_HAEIN DNA topoisomerase 4 subunit A 8 - - - -
P72525 PARC_STRPN DNA topoisomerase 4 subunit A (PARC_STRPN) 1 - - 11 -
P43702 PARC_HAEIN DNA topoisomerase 4 subunit A (PARC_HAEIN) 3 - - - -
P72525 PARC_STRPN DNA topoisomerase 4 subunit A (PARC_STRPN) 1 - - 11 -
P43702 PARC_HAEIN DNA topoisomerase 4 subunit A (PARC_HAEIN) 2 - - - -
P0AFI2 PARC_ECOLI DNA topoisomerase 4 subunit A (PARC_ECOLI) 1 - - 3 -
P43702 PARC_HAEIN DNA topoisomerase 4 subunit A (PARC_HAEIN) 1 - - - -
Q59961 PARE_STRPN DNA topoisomerase 4 subunit B 1 - - 11 -
Q969P6 TOP1M_HUMAN DNA topoisomerase I, mitochondrial 2 - - - -
P27695 APEX1_HUMAN DNA-(apurinic or apyrimidinic site) lyase 1 - - 13 -
P0A7Z4 RPOA_ECOLI DNA-directed RNA polymerase alpha chain 1 - - 27 -
P0A8V2 RPOB_ECOLI DNA-directed RNA polymerase beta chain 3 - - 13 1
P0A674 RPOC_MYCTO DNA-directed RNA polymerase beta' chain 1 - - - -
P0A8T7 RPOC_ECOLI DNA-directed RNA polymerase subunit beta' 2 - - 15 -
Q9BTZ2 DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 - - 1 1 -
P54886 P5CS_HUMAN Delta 1-pyrroline-5-carboxylate synthetase - - 1 1 -
P30038 AL4A1_HUMAN Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial - - 1 4 -
O95864 FADS2_HUMAN Delta-6 fatty acid desaturase - - 1 - -
P13716 HEM2_HUMAN Delta-aminolevulinic acid dehydratase 1 - - 3 -
P41143 OPRD_HUMAN Delta-type opioid receptor 24 - - 2 -
P27707 DCK_HUMAN Deoxycytidine kinase 1 - - 50 -
Dermatan sulfate - 2 - - -
P23743 DGKA_HUMAN Diacylglycerol kinase alpha - - 1 1 -
Q16760 DGKD_HUMAN Diacylglycerol kinase delta - - 1 2 -
P49619 DGKG_HUMAN Diacylglycerol kinase gamma - - 1 - -
Dietary fat - 4 - - -
P00374 DYR_HUMAN Dihydrofolate reductase 7 - 1 63 3
P09622 DLDH_HUMAN Dihydrolipoyl dehydrogenase, mitochondrial - - 1 5 1
P10515 ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial - - 1 12 -
Q08210 PYRD_PLAF7 Dihydroorotate dehydrogenase homolog, mitochondrial 1 - - 10 -
Q02127 PYRD_HUMAN Dihydroorotate dehydrogenase, mitochondrial 3 - - 35 -
Q49184 DHP1_MYCFO Dihydropterate synthase 1 - - - -
P09417 DHPR_HUMAN Dihydropteridine reductase - - 1 1 -
P0AC13 DHPS_ECOLI Dihydropteroate synthase 6 - - 3 1
P0C002 DHP1_ECOLX Dihydropteroate synthase (DHP1_ECOLX) 1 - - - -
P0AC13 DHPS_ECOLI Dihydropteroate synthase (DHPS_ECOLI) 3 - - 3 -
P0C0X1 DHPS1_MYCLE Dihydropteroate synthase 1 1 - - - -
P0C0X2 DHPS2_MYCLE Dihydropteroate synthase 2 1 - - - -
Q27738 Q27738_PLAFA Dihydropteroate synthetase 6 - - - -
P16444 DPEP1_HUMAN Dipeptidase 1 1 - - 2 1
P27487 DPP4_HUMAN Dipeptidyl peptidase 4 6 - - 89 5
Q16832 DDR2_HUMAN Discoidin domain-containing receptor 2 1 - - 2 -
P78352 DLG4_HUMAN Disks large homolog 4 1 - - 5 -
P09172 DOPO_HUMAN Dopamine beta-hydroxylase 2 - 1 - -
P24093 DRAA_ECOLX Dr hemagglutinin structural subunit 1 - - 6 3
Q9HCR9 PDE11_HUMAN Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1 - - - -
Q02750 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 2 - - 34 -
P36507 Dual specificity mitogen-activated protein kinase kinase 2 2 - - 2 -
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