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Index of protein targets for approved drugs and nutraceuticals

The alphabetical index below lists the proteins defined in DrugBank as the targets of approved drugs and nutraceuticals.

Names shown in purple are human proteins.

Columns: drug; biotech drug; nutraceutical; T   no. of target structures in the PDB; TD   no. of target-drug structures.

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C

UniProt accession and id Protein name T TD
P11586 C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic - - 2 4 -
Q15800 MSMO1_HUMAN C-4 methylsterol oxidase - - 1 - -
P51681 CCR5_HUMAN C-C chemokine receptor type 5 1 - - 8 -
P61073 CXCR4_HUMAN C-X-C chemokine receptor type 4 2 - - 8 -
C55-isoprenyl pyrophosphate 1 - - - -
P27708 PYR1_HUMAN CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase - - 1 15 -
Q9Y233 PDE10_HUMAN CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 4 - - 59 1
P16220 CREB1_HUMAN CAMP response element-binding protein 1 - 1 1 -
P27815 PDE4A_HUMAN CAMP-specific 3',5'-cyclic phosphodiesterase 4A 12 - - 3 1
Q07343 PDE4B_HUMAN CAMP-specific 3',5'-cyclic phosphodiesterase 4B 12 - 1 37 1
Q08493 PDE4C_HUMAN CAMP-specific 3',5'-cyclic phosphodiesterase 4C 5 - - 2 -
Q08499 PDE4D_HUMAN CAMP-specific 3',5'-cyclic phosphodiesterase 4D 5 - 1 36 2
Q9NP56 PDE7B_HUMAN CAMP-specific 3',5'-cyclic phosphodiesterase 7B 2 - - 1 -
P31358 CD52_HUMAN CAMPATH-1 antigen - 1 - - -
CD30 antigen 1 - - - -
P16070 CD44_HUMAN CD44 antigen 1 - - 3 -
Q8TED1 GPX8_HUMAN CDNA FLJ23636 fis, clone CAS07176 - - 1 2 -
O00408 PDE2A_HUMAN CGMP-dependent 3',5'-cyclic phosphodiesterase 1 - - 10 -
Q14432 PDE3A_HUMAN CGMP-inhibited 3',5'-cyclic phosphodiesterase A 11 - - 1 -
O76074 PDE5A_HUMAN CGMP-specific 3',5'-cyclic phosphodiesterase 8 - - 34 9
P17812 PYRG1_HUMAN CTP synthase 1 - - 1 3 -
P33151 CADH5_HUMAN Cadherin-5 1 - - - -
Cadmium 2 - - - -
Q96LZ3 CANB2_HUMAN Calcineurin subunit B isoform 2 1 - - - -
P30988 CALCR_HUMAN Calcitonin receptor - 2 - - -
Calcium ions 1 1 - - -
P49069 CAMLG_HUMAN Calcium signal-modulating cyclophilin ligand 1 - - - -
Q12791 KCMA1_HUMAN Calcium-activated potassium channel subunit alpha 1 9 - - 3 -
Q9Y691 KCMB2_HUMAN Calcium-activated potassium channel subunit beta 2 1 - - 1 -
Q16558 KCMB1_HUMAN Calcium-activated potassium channel subunit beta-1 1 - - - -
Q9NPA1 KCMB3_HUMAN Calcium-activated potassium channel subunit beta-3 1 - - - -
Q86W47 KCMB4_HUMAN Calcium-activated potassium channel subunit beta-4 1 - - - -
O75746 CMC1_HUMAN Calcium-binding mitochondrial carrier protein Aralar1 - - 1 - -
Q9UJS0 CMC2_HUMAN Calcium-binding mitochondrial carrier protein Aralar2 - - 1 - -
P98194 AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 6 - - - -
P54750 PDE1A_HUMAN Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3 - - 1 -
Q01064 PDE1B_HUMAN Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 3 - - 4 -
Q13555 KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II gamma chain 1 - - 2 -
P62158 CALM_HUMAN Calmodulin 15 - 1 95 1
P27824 CALX_HUMAN Calnexin - 2 - - -
P27797 CALR_HUMAN Calreticulin - 2 1 2 -
Q92887 MRP2_HUMAN Canalicular multispecific organic anion transporter 1 1 - 1 - -
P21554 CNR1_HUMAN Cannabinoid receptor 1 3 - - 2 -
P34972 CNR2_HUMAN Cannabinoid receptor 2 2 - - 1 -
P31327 CPSM_HUMAN Carbamoyl-phosphate synthase [ammonia], mitochondrial 1 - - 1 -
P00915 CAH1_HUMAN Carbonic anhydrase 1 20 - - 19 2
O43570 CAH12_HUMAN Carbonic anhydrase 12 4 - - 4 -
Q8N1Q1 CAH13_HUMAN Carbonic anhydrase 13 1 - - 5 -
Q9ULX7 CAH14_HUMAN Carbonic anhydrase 14 2 - - 1 1
P00918 CAH2_HUMAN Carbonic anhydrase 2 20 - - 479 23
P07451 CAH3_HUMAN Carbonic anhydrase 3 2 - - 7 -
P22748 CAH4_HUMAN Carbonic anhydrase 4 16 - - 5 1
P35218 CAH5A_HUMAN Carbonic anhydrase 5A, mitochondrial 2 - - - -
Q9Y2D0 CAH5B_HUMAN Carbonic anhydrase 5B, mitochondrial 1 - - - -
P23280 CAH6_HUMAN Carbonic anhydrase 6 1 - - 1 -
P43166 CAH7_HUMAN Carbonic anhydrase 7 5 - - 2 2
Q16790 CAH9_HUMAN Carbonic anhydrase 9 4 - - 1 -
P35219 CAH8_HUMAN Carbonic anhydrase-related protein 1 - - 1 -
Q9NS85 CAH10_HUMAN Carbonic anhydrase-related protein 10 1 - - - -
O75493 CAH11_HUMAN Carbonic anhydrase-related protein 11 1 - - - -
P16870 CBPE_HUMAN Carboxypeptidase E - 1 - - -
P13688 CEAM1_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 1 - 1 - 1 -
P43155 CACP_HUMAN Carnitine O-acetyltransferase 1 - - 2 1
P23786 CPT2_HUMAN Carnitine O-palmitoyltransferase 2, mitochondrial 2 - - - -
P50416 CPT1A_HUMAN Carnitine O-palmitoyltransferase I, liver isoform 2 - - 1 -
P29466 CASP1_HUMAN Caspase-1 1 - - 65 -
P42574 CASP3_HUMAN Caspase-3 1 - - 114 -
P04040 CATA_HUMAN Catalase 1 - - 6 -
P21964 COMT_HUMAN Catechol O-methyltransferase 2 - 1 6 3
P07339 CATD_HUMAN Cathepsin D - 1 - 13 -
P20645 MPRD_HUMAN Cation-dependent mannose-6-phosphate receptor - 1 - - -
P11717 MPRI_HUMAN Cation-independent mannose-6-phosphate receptor - 1 - 10 -
Q8WY07 CTR3_HUMAN Cationic amino acid transporter 3 - - 3 - -
O43246 CTR4_HUMAN Cationic amino acid transporter 4 - - 3 - -
P24941 CDK2_HUMAN Cell division protein kinase 2 1 - - 371 -
P12271 RLBP1_HUMAN Cellular retinaldehyde-binding protein - - 1 6 -
Q16739 CEGT_HUMAN Ceramide glucosyltransferase 1 - - - -
P00450 CERU_HUMAN Ceruloplasmin - 1 - 4 -
P33673 CHIS_BACCI Chitosanase 1 - - 2 -
P62580 CAT_SALTI Chloramphenicol acetyltransferase 1 - - - -
P00484 CAT3_ECOLX Chloramphenicol acetyltransferase 3 1 - - 6 1
P51788 CLCN2_HUMAN Chloride channel protein 2 1 - - - -
P51800 CLCKA_HUMAN Chloride channel protein ClC-Ka 1 - - 1 -
P32238 CCKAR_HUMAN Cholecystokinin type A receptor 1 - - 3 -
P05108 CP11A_HUMAN Cholesterol side-chain cleavage enzyme, mitochondrial 1 - - 4 -
P49585 PCY1A_HUMAN Choline-phosphate cytidylyltransferase A - - 1 - -
Q9Y5K3 PCY1B_HUMAN Choline-phosphate cytidylyltransferase B - - 1 - -
P06276 CHLE_HUMAN Cholinesterase 13 - 1 38 2
P54219 VMAT1_HUMAN Chromaffin granule amine transporter 1 - 1 - -
O14646 CHD1_HUMAN Chromodomain-helicase-DNA-binding protein 1 1 - - 13 -
Q96EM0 T3HPD_HUMAN Chromosome 14 open reading frame 149 - - 1 - -
P17538 CTRB1_HUMAN Chymotrypsinogen B - 1 - - -
P00748 FA12_HUMAN Coagulation Factor XII 1 - - 2 -
P00740 FA9_HUMAN Coagulation factor IX - 1 1 26 -
P12259 FA5_HUMAN Coagulation factor V - 1 - 7 -
P08709 FA7_HUMAN Coagulation factor VII - 2 1 113 -
P00451 FA8_HUMAN Coagulation factor VIII - 2 - 17 -
P00742 FA10_HUMAN Coagulation factor X 5 3 1 258 2
P03951 FA11_HUMAN Coagulation factor XI - 1 - 31 -
Q96EY8 MMAB_HUMAN Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial 1 - - 3 -
Q16568 CART_HUMAN Cocaine- and amphetamine-regulated transcript protein 1 - - 1 -
P02452 CO1A1_HUMAN Collagen alpha-1(I) chain - 1 - 9 -
P02458 CO2A1_HUMAN Collagen alpha-1(II) chain - 1 - 3 -
P02461 CO3A1_HUMAN Collagen alpha-1(III) chain - 1 - 9 -
P08123 CO1A2_HUMAN Collagen alpha-2(I) chain - 1 - - -
P45452 MMP13_HUMAN Collagenase 3 1 - - 42 -
P02745 C1QA_HUMAN Complement C1q subcomponent subunit A - 18 - 5 -
P02746 C1QB_HUMAN Complement C1q subcomponent subunit B - 18 - 5 -
P02747 C1QC_HUMAN Complement C1q subcomponent subunit C - 18 - 5 -
P00736 C1R_HUMAN Complement C1r subcomponent - 18 - 6 -
P09871 C1S_HUMAN Complement C1s subcomponent - 10 - 8 -
P01024 CO3_HUMAN Complement C3 - 1 - 63 -
P0C0L4 CO4A_HUMAN Complement C4-A - 1 - 7 -
P0C0L5 CO4B_HUMAN Complement C4-B - 1 - - -
P01031 CO5_HUMAN Complement C5 - 2 - 15 -
P68638 VCP_VACCW Complement control protein 1 - - 9 1
P08174 DAF_HUMAN Complement decay-accelerating factor 1 - - 21 -
Copper 1 - - - -
P06850 CRF_HUMAN Corticoliberin - 1 - 2 -
P28845 DHI1_HUMAN Corticosteroid 11-beta-dehydrogenase isozyme 1 1 - 1 38 -
P80365 DHI2_HUMAN Corticosteroid 11-beta-dehydrogenase isozyme 2 - - 1 - -
P01189 COLI_HUMAN Corticotropin-lipotropin 1 - - - -
P12277 KCRB_HUMAN Creatine kinase B-type - - 1 3 -
P06732 KCRM_HUMAN Creatine kinase M-type - - 1 1 -
P17540 KCRS_HUMAN Creatine kinase, sarcomeric mitochondrial - - 1 3 -
P12532 KCRU_HUMAN Creatine kinase, ubiquitous mitochondrial - - 1 1 -
O60494 CUBN_HUMAN Cubilin 1 - - 1 -
Q9F0I5 Q9F0I5_PAEMA Cycloinulo-oligosaccharide fructanotransferase - - 1 - -
P35520 CBS_HUMAN Cystathionine beta-synthase - - 3 9 1
P32929 CGL_HUMAN Cystathionine gamma-lyase - - 1 3 -
Q9Y697 NFS1_HUMAN Cysteine desulfurase, mitochondrial - - 2 - -
Q16857 Q16857_HUMAN Cysteine dioxygenase - - 1 - -
Q16878 CDO1_HUMAN Cysteine dioxygenase type 1 - - 2 1 1
Q9Y600 CSAD_HUMAN Cysteine sulfinic acid decarboxylase - - 1 1 -
Q9Y271 CLTR1_HUMAN Cysteinyl leukotriene receptor 1 5 - - - -
Q9NS75 CLTR2_HUMAN Cysteinyl leukotriene receptor 2 1 - - - -
P49589 SYCC_HUMAN Cysteinyl-tRNA synthetase, cytoplasmic - - 1 - -
P13569 CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator 5 - - 12 -
Cystine 1 - - - -
Q9UPY5 XCT_HUMAN Cystine/glutamate transporter 2 - 2 - -
O60931 CTNS_HUMAN Cystinosin - - 1 - -
P15538 C11B1_HUMAN Cytochrome P450 11B1, mitochondrial 2 - - - -
P05093 CP17A_HUMAN Cytochrome P450 17A1 2 - 1 2 -
P11511 CP19A_HUMAN Cytochrome P450 19A1 5 - - 7 1
P20813 CP2B6_HUMAN Cytochrome P450 2B6 1 - - 5 -
P10635 CP2D6_HUMAN Cytochrome P450 2D6 1 - - 4 -
P08684 CP3A4_HUMAN Cytochrome P450 3A4 1 - - 19 -
P20815 CP3A5_HUMAN Cytochrome P450 3A5 1 - - - -
Q02928 CP4AB_HUMAN Cytochrome P450 4A11 - - 1 - -
P10613 CP51_CANAL Cytochrome P450 51 7 - - - -
P50859 CP51_CANGA Cytochrome P450 51 (CP51_CANGA) 1 - - - -
P10613 CP51_CANAL Cytochrome P450 51 (CP51_CANAL) 5 - - - -
Q16850 CP51A_HUMAN Cytochrome P450 51A1 2 - - 4 -
P00183 CPXA_PSEPU Cytochrome P450-cam 1 - - 114 -
Q02768 CYB_PLAFA Cytochrome b 1 - - - -
P99999 CYC_HUMAN Cytochrome c 1 - - 4 -
P32927 IL3RB_HUMAN Cytokine receptor common beta chain - 1 - 6 -
P31785 IL2RG_HUMAN Cytokine receptor common gamma chain - 2 - 11 -
P47712 PA24A_HUMAN Cytosolic phospholipase A2 3 - - 3 -
P49902 5NTC_HUMAN Cytosolic purine 5'-nucleotidase 1 - 1 12 3
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