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Index of protein targets for approved drugs and nutraceuticals

The alphabetical index below lists the proteins defined in DrugBank as the targets of approved drugs and nutraceuticals.

Names shown in purple are human proteins.

Columns: drug; biotech drug; nutraceutical; T   no. of target structures in the PDB; TD   no. of target-drug structures.

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T

UniProt accession and id Protein name T TD
P06729 CD2_HUMAN T-cell surface antigen CD2 - 1 - 5 -
P06126 CD1A_HUMAN T-cell surface glycoprotein CD1a - 1 - 2 -
P04234 CD3D_HUMAN T-cell surface glycoprotein CD3 delta chain - 1 - 1 -
P07766 CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain - 1 - 4 -
P09693 CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain - 1 - - -
P20963 CD3Z_HUMAN T-cell surface glycoprotein CD3 zeta chain - 1 - 6 -
P01730 CD4_HUMAN T-cell surface glycoprotein CD4 - 1 - 44 -
P33681 CD80_HUMAN T-lymphocyte activation antigen CD80 - 2 - 2 -
P42081 CD86_HUMAN T-lymphocyte activation antigen CD86 - 3 - 2 -
O14717 TRDMT_HUMAN TRNA 1 - - 1 -
Q8TE23 TS1R2_HUMAN Taste receptor type 1 member 2 - - 1 - -
Teichoic acid - 1 - - -
O14746 TERT_HUMAN Telomerase reverse transcriptase 1 - - 1 -
Q58L87 Q58L87_MYCSM TetR family transcriptional repressor LfrR 1 - - 3 1
P05452 TETN_HUMAN Tetranectin - 1 - 4 -
Q9H3S4 TPK1_HUMAN Thiamin pyrophosphokinase 1 - - 1 2 1
O60779 S19A2_HUMAN Thiamine transporter 1 - - 1 - -
Q9BZV2 S19A3_HUMAN Thiamine transporter 2 - - 1 - -
P51580 TPMT_HUMAN Thiopurine S-methyltransferase 1 - - 2 -
O95881 TXD12_HUMAN Thioredoxin domain-containing protein 12 - - 1 2 -
P66010 TRXB_STAAM Thioredoxin reductase 1 - - - -
Q16881 TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic 1 - - 8 -
Q8IYQ7 THNS1_HUMAN Threonine synthase-like 1 - - 1 - -
P26639 SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic - - 1 2 -
Q9BW92 SYTM_HUMAN Threonyl-tRNA synthetase, mitochondrial - - 1 - -
P07204 TRBM_HUMAN Thrombomodulin 1 1 - 12 -
P40238 TPOR_HUMAN Thrombopoietin receptor 1 1 - - -
P21731 TA2R_HUMAN Thromboxane A2 receptor 1 - - 1 -
P24557 THAS_HUMAN Thromboxane-A synthase 1 - - - -
P06478 KITH_HHV1C Thymidine kinase 1 - - - -
Q9QNF7 KITH_HHV1 Thymidine kinase (KITH_HHV1) 3 - - - -
P03176 KITH_HHV11 Thymidine kinase (KITH_HHV11) 2 - - 38 3
P09250 KITH_VZVD Thymidine kinase (KITH_VZVD) 1 - - - -
P04818 TYSY_HUMAN Thymidylate synthase 2 - - 36 -
P12461 TYSY_CANAL Thymidylate synthase (TYSY_CANAL) 1 - - - -
P04818 TYSY_HUMAN Thymidylate synthase (TYSY_HUMAN) 8 - - 36 4
P10827 THA_HUMAN Thyroid hormone receptor alpha 4 - - 8 1
P10828 THB_HUMAN Thyroid hormone receptor beta-1 4 - - 19 1
P07202 PERT_HUMAN Thyroid peroxidase 4 - - - -
P16473 TSHR_HUMAN Thyrotropin receptor - 1 - 2 -
P13726 TF_HUMAN Tissue factor - 1 - 48 -
P10646 TFPI1_HUMAN Tissue factor pathway inhibitor 1 1 - 6 -
P00750 TPA_HUMAN Tissue-type plasminogen activator 3 1 - 9 1
O60603 TLR2_HUMAN Toll-like receptor 2 - 1 - 5 -
O00206 TLR4_HUMAN Toll-like receptor 4 1 - - 10 -
Q9NYK1 TLR7_HUMAN Toll-like receptor 7 2 - - - -
Q9NR97 TLR8_HUMAN Toll-like receptor 8 1 - - 7 -
Q9NR96 TLR9_HUMAN Toll-like receptor 9 2 - - - -
Q96RJ0 TAAR1_HUMAN Trace amine-associated receptor 1 4 - - - -
P20061 TCO1_HUMAN Transcobalamin-1 1 - - 3 -
P05412 JUN_HUMAN Transcription factor AP-1 3 - - 7 -
Transferrin Receptor Protein 1 - - - -
P01137 TGFB1_HUMAN Transforming growth factor beta-1 - 1 - 4 -
O75762 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 1 - - - -
Q7Z2W7 TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 1 - - - -
Q8NER1 TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 - - 3 - -
Q8NET8 TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 1 - - - -
P30536 TSPOA_HUMAN Translocator protein 13 - - - -
O67854 O67854_AQUAE Transporter 3 - - 50 6
P40939 ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial - - 1 - -
P22102 PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase 1 - - 17 -
Q9NVH6 TMLH_HUMAN Trimethyllysine dioxygenase, mitochondrial - - 2 - -
Trivalent metal cations 1 - - - -
P02585 TNNC2_HUMAN Troponin C, skeletal muscle 1 - - - -
P63316 TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles 5 - - 32 3
P07477 TRY1_HUMAN Trypsin-1 - 1 - 3 -
P17752 TPH1_HUMAN Tryptophan 5-hydroxylase 1 1 - - 4 -
P00953 SYW_GEOSE Tryptophanyl-tRNA synthetase - - 1 12 3
Q9RVD6 SYW2_DEIRA Tryptophanyl-tRNA synthetase 2 - - 1 4 -
P23381 SYWC_HUMAN Tryptophanyl-tRNA synthetase, cytoplasmic - - 1 14 4
Q9UGM6 SYWM_HUMAN Tryptophanyl-tRNA synthetase, mitochondrial - - 1 - -
P87066 TBA_CANAX Tubulin alpha chain 1 - - - -
P68366 TBA4A_HUMAN Tubulin alpha-1 chain 3 - - - -
Q71U36 TBA1A_HUMAN Tubulin alpha-3 chain 3 - - - -
P07437 TBB5_HUMAN Tubulin beta chain 4 - - - -
P10875 TBB_CANAX Tubulin beta chain (TBB_CANAX) 1 - - - -
P07437 TBB5_HUMAN Tubulin beta chain (TBB5_HUMAN) 1 - - - -
Q9H4B7 TBB1_HUMAN Tubulin beta-1 chain 5 - - - -
P68371 TBB2C_HUMAN Tubulin beta-2C chain 2 - - - -
Q13509 TBB3_HUMAN Tubulin beta-3 chain 1 - - - -
Q9UJT1 TBD_HUMAN Tubulin delta chain 1 - - - -
Q9UJT0 TBE_HUMAN Tubulin epsilon chain 1 - - - -
P23258 TBG1_HUMAN Tubulin gamma-1 chain 1 - - 3 -
P01375 TNFA_HUMAN Tumor necrosis factor 7 5 - 18 -
O14788 TNF11_HUMAN Tumor necrosis factor ligand superfamily member 11 1 1 - 1 -
Q9Y275 TN13B_HUMAN Tumor necrosis factor ligand superfamily member 13B - 1 - 8 -
P20333 TNR1B_HUMAN Tumor necrosis factor receptor superfamily member 1B - 1 - 1 -
P30556 AGTR1_HUMAN Type-1 angiotensin II receptor 11 - - 1 -
P50052 AGTR2_HUMAN Type-2 angiotensin II receptor 1 - - - -
P14679 TYRO_HUMAN Tyrosinase 3 - 1 - -
Tyrosine 1 - - - -
P07101 TY3H_HUMAN Tyrosine 3-monooxygenase 2 - 2 1 -
P17735 ATTY_HUMAN Tyrosine aminotransferase - - 3 1 -
P42684 ABL2_HUMAN Tyrosine-protein kinase ABL2 1 - 1 8 -
P42685 FRK_HUMAN Tyrosine-protein kinase FRK 1 - - - -
P08631 HCK_HUMAN Tyrosine-protein kinase HCK 1 - - 33 -
Q08881 ITK_HUMAN Tyrosine-protein kinase ITK/TSK 1 - - 37 -
P23458 JAK1_HUMAN Tyrosine-protein kinase JAK1 1 - - 19 -
O60674 JAK2_HUMAN Tyrosine-protein kinase JAK2 1 - - 43 -
P07948 LYN_HUMAN Tyrosine-protein kinase Lyn 2 - - 3 -
P18031 PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 1 - - 125 -
P29074 PTN4_HUMAN Tyrosine-protein phosphatase non-receptor type 4 1 - - 8 -
P54577 SYYC_HUMAN Tyrosyl-tRNA synthetase, cytoplasmic - - 1 3 -
Q9Y2Z4 SYYM_HUMAN Tyrosyl-tRNA synthetase, mitochondrial - - 1 2 -
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