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Index of protein targets for approved drugs and nutraceuticals

The alphabetical index below lists the proteins defined in DrugBank as the targets of approved drugs and nutraceuticals.

Names shown in purple are human proteins.

Columns: drug; biotech drug; nutraceutical; T   no. of target structures in the PDB; TD   no. of target-drug structures.

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UniProt accession and id Protein name T TD
P17707 DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme - - 1 49 -
Q00266 METK1_HUMAN S-adenosylmethionine synthetase isoform type-1 - - 1 1 1
P31153 METK2_HUMAN S-adenosylmethionine synthetase isoform type-2 - - 1 8 4
P10768 ESTD_HUMAN S-formylglutathione hydrolase - - 1 2 -
Q13126 MTAP_HUMAN S-methyl-5-thioadenosine phosphorylase - - 1 9 1
O76054 S14L2_HUMAN SEC14-like protein 2 - - 1 2 -
Q9UDX4 S14L3_HUMAN SEC14-like protein 3 - - 1 - -
Q9UDX3 S14L4_HUMAN SEC14-like protein 4 - - 1 1 -
Q9UQQ2 SH2B3_HUMAN SH2B adapter protein 3 1 - - - -
Q8N1A5 Q8N1A5_HUMAN SHMT2 protein - - 1 - -
Q5BJF5 Q5BJF5_HUMAN SHMT2 protein (Q5BJF5_HUMAN) - - 1 - -
Q8N1A5 Q8N1A5_HUMAN SHMT2 protein (Q8N1A5_HUMAN) - - 1 - -
Q5BJF5 Q5BJF5_HUMAN SHMT2 protein (Q5BJF5_HUMAN) - - 1 - -
Q8WTV0 SCRB1_HUMAN Scavenger receptor class B member 1 - - 1 - -
Schistosome Calcium (Ca 2+) Channel 1 - - - -
P47872 SCTR_HUMAN Secretin receptor - 1 - - -
Q53ET4 Q53ET4_HUMAN Serine hydroxymethyltransferase 2 - - 2 - -
P34896 GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic 1 - 2 1 -
P34897 GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial - - 2 2 -
O15269 SPTC1_HUMAN Serine palmitoyltransferase 1 - - 1 - -
O15270 SPTC2_HUMAN Serine palmitoyltransferase 2 - - 1 - -
P05981 HEPS_HUMAN Serine protease hepsin 1 1 - 8 -
Q9GZT4 SRR_HUMAN Serine racemase - - 1 2 -
P21549 SPYA_HUMAN Serine--pyruvate aminotransferase - - 3 8 -
Q96Q40 CDK15_HUMAN Serine/threonine-protein kinase ALS2CR7 - - 1 - -
Q8NG66 NEK11_HUMAN Serine/threonine-protein kinase Nek11 1 - - - -
P57059 SIK1_HUMAN Serine/threonine-protein kinase SIK1 1 - - - -
P78362 SRPK2_HUMAN Serine/threonine-protein kinase SRPK2 - - 1 1 -
P42345 MTOR_HUMAN Serine/threonine-protein kinase mTOR 4 - - 19 -
P37023 ACVL1_HUMAN Serine/threonine-protein kinase receptor R3 - - 1 6 -
P67775 PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform - - 1 17 -
P62714 PP2AB_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform - - 1 - -
P02787 TRFE_HUMAN Serotransferrin 1 - - 36 -
P35237 SPB6_HUMAN Serpin B6 - 1 - - -
P02735 SAA_HUMAN Serum amyloid A protein - 2 - - -
P27169 PON1_HUMAN Serum paraoxonase/arylesterase 1 1 - - 2 -
P49591 SYSC_HUMAN Seryl-tRNA synthetase, cytoplasmic - - 1 2 -
O75911 DHRS3_HUMAN Short-chain dehydrogenase/reductase 3 - - 1 - -
P16219 ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial - - 1 1 -
P45954 ACDSB_HUMAN Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 1 - 1 1 -
Q99519 NEUR1_HUMAN Sialidase-1 1 - - - -
Q9Y3R4 NEUR2_HUMAN Sialidase-2 2 - - 16 1
Q99720 SGMR1_HUMAN Sigma 1-type opioid receptor 3 - - - -
P51692 STA5B_HUMAN Signal transducer and activator of transcription 5B 1 - - - -
Q92952 KCNN1_HUMAN Small conductance calcium-activated potassium channel protein 1 1 - - - -
Q9H2S1 KCNN2_HUMAN Small conductance calcium-activated potassium channel protein 2 1 - - - -
Q9UGI6 KCNN3_HUMAN Small conductance calcium-activated potassium channel protein 3 1 - - - -
P13500 CCL2_HUMAN Small inducible cytokine A2 2 - - 10 -
Q99835 SMO_HUMAN Smoothened homolog 2 - - 5 -
P35498 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha 8 - - - -
Q9Y5Y9 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha 16 - - - -
Q9UI33 SCNBA_HUMAN Sodium channel protein type 11 subunit alpha 2 - - - -
Q99250 SCN2A_HUMAN Sodium channel protein type 2 subunit alpha 3 - - 2 -
Q9NY46 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha 2 - - - -
P35499 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha 4 - - - -
Q14524 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha 29 - - 5 -
Q15858 SCN9A_HUMAN Sodium channel protein type 9 subunit alpha 5 - - - -
Q07699 SCN1B_HUMAN Sodium channel subunit beta-1 1 - - - -
O60939 SCN2B_HUMAN Sodium channel subunit beta-2 1 - - - -
Q9NY72 SCN3B_HUMAN Sodium channel subunit beta-3 1 - - 1 -
Q8IWT1 SCN4B_HUMAN Sodium channel subunit beta-4 1 - - 2 -
P30531 SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 1 - - - -
P48029 SC6A8_HUMAN Sodium- and chloride-dependent creatine transporter 1 - - 1 - -
P48067 SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 - - 1 - -
Q9Y345 SC6A5_HUMAN Sodium- and chloride-dependent glycine transporter 2 - - 1 - -
Q9UN76 S6A14_HUMAN Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) - - 1 - -
Q01959 SC6A3_HUMAN Sodium-dependent dopamine transporter 29 - 1 - -
Q9Y289 SC5A6_HUMAN Sodium-dependent multivitamin transporter - - 2 - -
P23975 SC6A2_HUMAN Sodium-dependent noradrenaline transporter 44 - 2 - -
Q99884 SC6A7_HUMAN Sodium-dependent proline transporter - - 1 - -
P31645 SC6A4_HUMAN Sodium-dependent serotonin transporter 39 - 1 - -
P32418 NAC1_HUMAN Sodium/calcium exchanger 1 - - 2 - -
P13866 SC5A1_HUMAN Sodium/glucose cotransporter 1 1 - - - -
P31639 SC5A2_HUMAN Sodium/glucose cotransporter 2 1 - - - -
P19634 SL9A1_HUMAN Sodium/hydrogen exchanger 1 1 - - 7 -
P05023 AT1A1_HUMAN Sodium/potassium-transporting ATPase alpha-1 chain 13 - - - -
P54710 ATNG_HUMAN Sodium/potassium-transporting ATPase gamma chain 1 - - 1 -
Q13621 S12A1_HUMAN Solute carrier family 12 member 1 11 - - - -
P55011 S12A2_HUMAN Solute carrier family 12 member 2 3 - - - -
P55017 S12A3_HUMAN Solute carrier family 12 member 3 8 - - - -
Q9UP95 S12A4_HUMAN Solute carrier family 12 member 4 2 - - - -
Q9H2X9 S12A5_HUMAN Solute carrier family 12 member 5 2 - - - -
Q9UHW9 S12A6_HUMAN Solute carrier family 12 member 6 1 - - - -
Q9Y666 S12A7_HUMAN Solute carrier family 12 member 7 1 - - - -
Q9BZW2 S13A1_HUMAN Solute carrier family 13 member 1 - - 1 - -
Q13183 S13A2_HUMAN Solute carrier family 13 member 2 - - 1 - -
Q8WWT9 S13A3_HUMAN Solute carrier family 13 member 3 - - 1 - -
P11168 GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 1 - - - -
Q9NSA0 S22AB_HUMAN Solute carrier family 22 member 11 1 - - - -
Q4U2R8 S22A6_HUMAN Solute carrier family 22 member 6 1 - - - -
Q8TCC7 S22A8_HUMAN Solute carrier family 22 member 8 1 - - - -
Q9UHI7 S23A1_HUMAN Solute carrier family 23 member 1 - - 1 - -
O94956 SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 1 - - - -
P61278 SMS_HUMAN Somatostatin 1 - - 1 -
P30872 SSR1_HUMAN Somatostatin receptor type 1 2 - - - -
P30874 SSR2_HUMAN Somatostatin receptor type 2 3 - - - -
P32745 SSR3_HUMAN Somatostatin receptor type 3 1 - - - -
P35346 SSR5_HUMAN Somatostatin receptor type 5 3 - - - -
Q00796 DHSO_HUMAN Sorbitol dehydrogenase - - 1 3 -
Q9NWM0 SMOX_HUMAN Spermine oxidase - - 1 - -
P52788 SPSY_HUMAN Spermine synthase - - 1 6 1
P17405 ASM_HUMAN Sphingomyelin phosphodiesterase 1 - - 1 -
Q9NY59 NSMA2_HUMAN Sphingomyelin phosphodiesterase 3 - - 1 - -
Q9NXE4 NSMA3_HUMAN Sphingomyelin phosphodiesterase 4 - - 1 - -
Q9H228 S1PR5_HUMAN Sphingosine 1-phosphate receptor Edg-8 1 - - - -
Q14534 ERG1_HUMAN Squalene monooxygenase 2 - - - -
Q92206 ERG1_CANAL Squalene monooxygenase (ERG1_CANAL) 1 - - - -
Q14534 ERG1_HUMAN Squalene monooxygenase (ERG1_HUMAN) 1 - - - -
Stanozolol Binding Protein (STBP) 1 - - - -
Q9H169 STMN4_HUMAN Stathmin-4 1 - - - -
P35610 SOAT1_HUMAN Sterol O-acyltransferase 1 2 - - - -
O75908 SOAT2_HUMAN Sterol O-acyltransferase 2 1 - - - -
Q15738 NSDHL_HUMAN Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating - - 1 - -
P50870 VATD_ENTFC Streptogramin A acetyltransferase 1 - - 8 1
P48061 SDF1_HUMAN Stromal cell-derived factor 1 1 - - 22 -
P08254 MMP3_HUMAN Stromelysin-1 1 - - 43 -
P09238 MMP10_HUMAN Stromelysin-2 1 - - 3 -
P24347 MMP11_HUMAN Stromelysin-3 1 - - - -
P25103 NK1R_HUMAN Substance-P receptor 3 - - 3 -
O14521 DHSD_HUMAN Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial 1 - 1 - -
P31040 DHSA_HUMAN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial - - 1 - -
P21912 SDHB_HUMAN Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial - - 1 - -
Q99643 C560_HUMAN Succinate dehydrogenase cytochrome b560 subunit, mitochondrial - - 1 - -
Q9BXA5 SUCR1_HUMAN Succinate receptor 1 - - 1 - -
P51649 SSDH_HUMAN Succinate semialdehyde dehydrogenase, mitochondrial 2 - 2 5 1
Q9P2R7 SUCB1_HUMAN Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial - - 1 - -
Q96I99 SUCB2_HUMAN Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial - - 1 - -
P53597 SUCA_HUMAN Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial - - 1 - -
P55809 SCOT1_HUMAN Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial - - 1 1 -
Q9BYC2 SCOT2_HUMAN Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial - - 1 - -
P14410 SUIS_HUMAN Sucrase-isomaltase, intestinal 2 - - 2 -
Q9Y5Y6 ST14_HUMAN Suppressor of tumorigenicity protein 14 - 1 - 20 -
Q7L0J3 SV2A_HUMAN Synaptic vesicle glycoprotein 2A 1 - - - -
Q05940 VMAT2_HUMAN Synaptic vesicular amine transporter 11 - 1 - -
P60880 SNP25_HUMAN Synaptosomal-associated protein 25 - 1 - 10 -
Q8N9I0 SYT2_HUMAN Synaptotagmin-2 - 1 - - -
Q96C24 SYTL4_HUMAN Synaptotagmin-like protein 4 - 1 - 2 -
P34741 SDC2_HUMAN Syndecan-2 - 1 - - -
Q99624 S38A3_HUMAN System N amino acid transporter 1 - - 2 - -
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