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Index of protein targets for approved drugs and nutraceuticals

The alphabetical index below lists the proteins defined in DrugBank as the targets of approved drugs and nutraceuticals.

Names shown in purple are human proteins.

Columns: drug; biotech drug; nutraceutical; T   no. of target structures in the PDB; TD   no. of target-drug structures.

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UniProt accession and id Protein name T TD
N-acetyl-p-benzoquinoneimine 1 - - - -
Q9UJ70 NAGK_HUMAN N-acetylglucosamine kinase - - 1 3 1
Q9UK23 NAGPA_HUMAN N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase - - 1 - -
Q8N159 NAGS_HUMAN N-acetylglutamate synthase, mitochondrial - - 1 1 -
P51606 RENBP_HUMAN N-acylglucosamine 2-epimerase - - 1 - -
Q14330 GPR18_HUMAN N-arachidonyl glycine receptor - - 1 - -
Q13423 NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial - - 1 3 -
P15559 NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 1 - 1 12 -
Q9NXA8 SIR5_HUMAN NAD-dependent deacetylase sirtuin-5 1 - - 9 2
P23368 MAOM_HUMAN NAD-dependent malic enzyme, mitochondrial - - 1 10 1
O15239 NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 - - 1 - -
O95299 NDUAA_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial - - 1 - -
Q86Y39 NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 - - 1 - -
Q9UI09 NDUAC_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 - - 1 - -
Q9P0J0 NDUAD_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 - - 1 - -
O43678 NDUA2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 - - 1 1 -
O95167 NDUA3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 - - 1 - -
O00483 NDUA4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 - - 1 - -
Q9NRX3 NUA4L_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 - - 1 - -
Q16718 NDUA5_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 - - 1 - -
P56556 NDUA6_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 - - 1 - -
O95182 NDUA7_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 - - 1 - -
P51970 NDUA8_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 - - 1 - -
Q16795 NDUA9_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial - - 1 - -
O75438 NDUB1_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 - - 1 - -
O96000 NDUBA_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 - - 1 - -
O95178 NDUB2_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial - - 1 - -
O43676 NDUB3_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 - - 1 - -
O95168 NDUB4_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 - - 1 - -
O43674 NDUB5_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial - - 1 - -
O95139 NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 - - 1 - -
P17568 NDUB7_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 - - 1 - -
O95169 NDUB8_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial - - 1 - -
Q9Y6M9 NDUB9_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 - - 1 - -
O43677 NDUC1_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial - - 1 - -
O95298 NDUC2_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C2 1 - 1 - -
P49821 NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial - - 1 - -
P19404 NDUV2_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial - - 1 - -
P56181 NDUV3_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial - - 1 - -
O75306 NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial - - 1 - -
O75489 NDUS3_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial - - 1 - -
O43181 NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial - - 1 - -
O43920 NDUS5_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 - - 1 - -
O75380 NDUS6_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial - - 1 - -
O75251 NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial - - 1 - -
O00217 NDUS8_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial - - 1 - -
P00387 NB5R3_HUMAN NADH-cytochrome b5 reductase 3 - - 1 2 -
P28331 NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial - - 1 - -
P03886 NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 5 - 1 - -
P03891 NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 - - 1 - -
P03897 NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3 - - 1 - -
P03905 NU4M_HUMAN NADH-ubiquinone oxidoreductase chain 4 - - 1 - -
P03901 NU4LM_HUMAN NADH-ubiquinone oxidoreductase chain 4L - - 1 - -
P03915 NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5 - - 1 - -
P03923 NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6 - - 1 - -
P48163 MAOX_HUMAN NADP-dependent malic enzyme - - 1 2 -
Q16798 MAON_HUMAN NADP-dependent malic enzyme, mitochondrial - - 1 - -
Q8NFA2 NOXO1_HUMAN NADPH oxidase organizer 1 1 - - 1 -
Q13564 ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subunit - - 1 9 2
O94760 DDAH1_HUMAN NG,NG-dimethylarginine dimethylaminohydrolase 1 - - 1 7 1
O95865 DDAH2_HUMAN NG,NG-dimethylarginine dimethylaminohydrolase 2 - - 1 - -
P16860 ANFB_HUMAN Natriuretic peptides B 1 - - 1 -
P08473 NEP_HUMAN Neprilysin 1 - - 11 -
P27907 NRAM_INBBE Neuraminidase 1 - - 5 1
P06818 NRAM_I79A0 Neuraminidase (NRAM_I79A0) 1 - - - -
P11485 NRAM_I83A1 Neuraminidase (NRAM_I83A1) 1 - - - -
P29120 NEC1_HUMAN Neuroendocrine convertase 1 - 1 - - -
P16519 NEC2_HUMAN Neuroendocrine convertase 2 - 1 - - -
Q9GZZ6 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10 7 - - - -
Q15822 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 20 - - - -
P32297 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 7 - - 1 -
P43681 ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 18 - - 2 -
P30532 ACHA5_HUMAN Neuronal acetylcholine receptor subunit alpha-5 2 - - - -
Q15825 ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6 3 - - - -
P36544 ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 18 - - 1 -
Q9UGM1 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9 2 - - - -
P17787 ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2 2 - - 5 -
Q05901 ACHB3_HUMAN Neuronal acetylcholine receptor subunit beta-3 2 - - - -
P30926 ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 4 - - 1 -
Q6W5P4 NPSR1_HUMAN Neuropeptide S receptor 1 - - - -
P49146 NPY2R_HUMAN Neuropeptide Y receptor type 2 1 - - - -
O14786 NRP1_HUMAN Neuropilin-1 - 2 - 6 -
O95665 NTR2_HUMAN Neurotensin receptor type 2 1 - - - -
Q14697 GANAB_HUMAN Neutral alpha-glucosidase AB 1 - - - -
Q8TET4 GANC_HUMAN Neutral alpha-glucosidase C 1 - - - -
P43007 SATT_HUMAN Neutral amino acid transporter A - - 1 - -
Q15758 AAAT_HUMAN Neutral amino acid transporter B(0) - - 1 - -
Q07837 SLC31_HUMAN Neutral and basic amino acid transport protein rBAT - - 1 - -
P22894 MMP8_HUMAN Neutrophil collagenase 1 - - 23 -
P40261 NNMT_HUMAN Nicotinamide N-methyltransferase - - 1 3 -
Q15274 NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating] - - 1 5 -
Q05603 COBT_SALTY Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase - - 1 34 2
Q8TDS4 HCAR2_HUMAN Nicotinic acid receptor 1 - - 1 - -
P49019 HCAR3_HUMAN Nicotinic acid receptor 2 - - 1 - -
P14543 NID1_HUMAN Nidogen-1 - 1 - 1 -
Q9UHC9 NPCL1_HUMAN Niemann-Pick C1-like protein 1 1 - - 1 -
Q9Y2I1 NISCH_HUMAN Nischarin 1 - - 1 -
P35228 NOS2_HUMAN Nitric oxide synthase, inducible 3 - 2 8 -
P29475 NOS1_HUMAN Nitric-oxide synthase, brain - - 1 - -
P29474 NOS3_HUMAN Nitric-oxide synthase, endothelial 2 - 2 10 -
Q00653 NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit 1 - - 3 -
P19838 NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit 3 - - 8 -
P51843 NR0B1_HUMAN Nuclear receptor 0B1 1 - 1 - -
Q92753 RORB_HUMAN Nuclear receptor ROR-beta - - 1 - -
O75469 NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 7 - 1 11 1
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