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Index of protein targets for approved drugs and nutraceuticals

The alphabetical index below lists the proteins defined in DrugBank as the targets of approved drugs and nutraceuticals.

Names shown in purple are human proteins.

Columns: drug; biotech drug; nutraceutical; T   no. of target structures in the PDB; TD   no. of target-drug structures.

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UniProt accession and id Protein name T TD
P10398 ARAF_HUMAN A-Raf proto-oncogene serine/threonine-protein kinase - - 1 1 -
P17802 MUTY_ECOLI A/G-specific adenine glycosylase - - 1 13 2
P12235 ADT1_HUMAN ADP/ATP translocase 1 1 - 1 - -
P05141 ADT2_HUMAN ADP/ATP translocase 2 1 - - - -
P12236 ADT3_HUMAN ADP/ATP translocase 3 1 - - - -
Q9Y4W6 AFG32_HUMAN AFG3-like protein 2 - - 1 1 -
Q9UM73 ALK_HUMAN ALK tyrosine kinase receptor - - 1 39 -
P02760 AMBP_HUMAN AMBP protein - 2 - 3 -
Q96IG6 GCST_HUMAN AMT protein - - 1 - -
Q7L266 ASGL1_HUMAN ASRGL1 protein - - 2 20 1
P30049 ATPD_HUMAN ATP synthase delta chain, mitochondrial 6 - - - -
P63691 ATPL_MYCTO ATP synthase subunit c 1 - - - -
O95477 ABCA1_HUMAN ATP-binding cassette sub-family A member 1 2 - 1 - -
P45844 ABCG1_HUMAN ATP-binding cassette sub-family G member 1 - - 1 - -
Q09428 ABCC8_HUMAN ATP-binding cassette transporter sub-family C member 8 11 - 1 - -
O60706 ABCC9_HUMAN ATP-binding cassette transporter sub-family C member 9 1 - 1 - -
P48048 IRK1_HUMAN ATP-sensitive inward rectifier potassium channel 1 8 - - - -
Q14654 IRK11_HUMAN ATP-sensitive inward rectifier potassium channel 11 7 - - - -
Q14500 KCJ12_HUMAN ATP-sensitive inward rectifier potassium channel 12 1 - - - -
Q15842 IRK8_HUMAN ATP-sensitive inward rectifier potassium channel 8 5 - - - -
O67135 O67135_AQUAE Acetoin utilization protein 1 - - 3 1
P24752 THIL_HUMAN Acetyl-CoA acetyltransferase, mitochondrial 1 - - 8 -
Q13085 ACACA_HUMAN Acetyl-CoA carboxylase 1 - - 1 3 -
O00763 ACACB_HUMAN Acetyl-CoA carboxylase 2 - - 2 10 -
Q9NUB1 ACS2L_HUMAN Acetyl-coenzyme A synthetase 2-like, mitochondrial - - 2 - -
Q9NR19 ACSA_HUMAN Acetyl-coenzyme A synthetase, cytoplasmic - - 2 - -
P02708 ACHA_HUMAN Acetylcholine receptor subunit alpha 1 - - - -
P11230 ACHB_HUMAN Acetylcholine receptor subunit beta 1 - - - -
Q07001 ACHD_HUMAN Acetylcholine receptor subunit delta 1 - - - -
Q04844 ACHE_HUMAN Acetylcholine receptor subunit epsilon 1 - - 1 -
P07510 ACHG_HUMAN Acetylcholine receptor subunit gamma 1 - - - -
P22303 ACES_HUMAN Acetylcholinesterase 17 - 1 20 2
Q07912 ACK1_HUMAN Activated CDC42 kinase 1 - - 1 12 -
P36896 ACV1B_HUMAN Activin receptor type 1B - - 1 - -
Q04771 ACVR1_HUMAN Activin receptor type-1 - - 1 6 -
O14561 ACPM_HUMAN Acyl carrier protein, mitochondrial - - 1 1 -
P07741 APT_HUMAN Adenine phosphoribosyltransferase - - 1 5 1
Adenosine - 1 - - -
P30542 AA1R_HUMAN Adenosine A1 receptor 9 1 - - -
P29274 AA2AR_HUMAN Adenosine A2a receptor 9 1 - 20 2
P29275 AA2BR_HUMAN Adenosine A2b receptor 3 1 - - -
P33765 AA3R_HUMAN Adenosine A3 receptor 2 - - 3 -
P00813 ADA_HUMAN Adenosine deaminase 2 - - 2 -
P55263 ADK_HUMAN Adenosine kinase 1 - 1 3 -
Q08828 ADCY1_HUMAN Adenylate cyclase type 1 - - 2 - -
Q5SY84 Q5SY84_HUMAN Adenylosuccinate synthetase - - 1 - -
Q8N142 PURA1_HUMAN Adenylosuccinate synthetase isozyme 1 - - 1 1 -
P30520 PURA2_HUMAN Adenylosuccinate synthetase isozyme 2 - - 1 1 -
Q01718 ACTHR_HUMAN Adrenocorticotropic hormone receptor - 2 - - -
P10109 ADX_HUMAN Adrenodoxin, mitochondrial 1 - - 6 -
P24298 ALAT1_HUMAN Alanine aminotransferase 1 1 - 2 - -
Q8TD30 ALAT2_HUMAN Alanine aminotransferase 2 1 - 2 1 -
Q9L888 ALR_MYCAV Alanine racemase 1 - - - -
Q9BYV1 AGT2_HUMAN Alanine--glyoxylate aminotransferase 2, mitochondrial - - 3 - -
Q8IUZ5 AT2L2_HUMAN Alanine--glyoxylate aminotransferase 2-like 2 - - 1 - -
P49588 SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic - - 1 - -
P07327 ADH1A_HUMAN Alcohol dehydrogenase 1A 2 - 1 2 -
P00325 ADH1B_HUMAN Alcohol dehydrogenase 1B 2 - 1 9 -
P00326 ADH1G_HUMAN Alcohol dehydrogenase 1C 2 - 1 3 -
P08319 ADH4_HUMAN Alcohol dehydrogenase 4 - - 1 1 -
P11766 ADHX_HUMAN Alcohol dehydrogenase class 3 - - 1 9 -
P40394 ADH7_HUMAN Alcohol dehydrogenase class 4 mu/sigma chain - - 1 3 -
P47895 AL1A3_HUMAN Aldehyde dehydrogenase 1A3 - - 2 - -
P43353 AL3B1_HUMAN Aldehyde dehydrogenase 3B1 - - 1 - -
P48448 AL3B2_HUMAN Aldehyde dehydrogenase 3B2 - - 1 - -
P30837 AL1B1_HUMAN Aldehyde dehydrogenase X, mitochondrial - - 1 - -
P30838 AL3A1_HUMAN Aldehyde dehydrogenase, dimeric NADP-preferring - - 1 5 -
P05091 ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial 2 - 1 27 16
Q04828 AK1C1_HUMAN Aldo-keto reductase family 1 member C1 2 - 1 4 -
P52895 AK1C2_HUMAN Aldo-keto reductase family 1 member C2 1 - 1 14 1
P42330 AK1C3_HUMAN Aldo-keto reductase family 1 member C3 1 - 1 30 1
P17516 AK1C4_HUMAN Aldo-keto reductase family 1 member C4 - - 1 1 -
P15121 ALDR_HUMAN Aldose reductase 1 - 1 120 2
P10696 PPBN_HUMAN Alkaline phosphatase, placental-like 2 - - - -
Q6NUM9 RETST_HUMAN All-trans-retinol 13,14-reductase - - 1 - -
P16234 PGFRA_HUMAN Alpha platelet-derived growth factor receptor 5 1 - - -
P35348 ADA1A_HUMAN Alpha-1A adrenergic receptor 78 - - - -
P35368 ADA1B_HUMAN Alpha-1B adrenergic receptor 43 - - - -
P25100 ADA1D_HUMAN Alpha-1D adrenergic receptor 26 - - - -
P08697 A2AP_HUMAN Alpha-2-antiplasmin - 1 - - -
P01023 A2MG_HUMAN Alpha-2-macroglobulin 1 2 - 5 -
P08913 ADA2A_HUMAN Alpha-2A adrenergic receptor 58 - 1 4 -
P18089 ADA2B_HUMAN Alpha-2B adrenergic receptor 34 - 1 1 -
P18825 ADA2C_HUMAN Alpha-2C adrenergic receptor 31 - 1 - -
Q693P7 Q693P7_HUMAN Alpha-7 nicotinic cholinergic receptor subunit 3 - - - -
P54802 ANAG_HUMAN Alpha-N-acetylglucosaminidase - - 1 - -
P49419 AL7A1_HUMAN Alpha-aminoadipic semialdehyde dehydrogenase - - 1 1 1
Q9UDR5 AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial - - 2 - -
Q6NS38 ALKB2_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 - - 1 18 -
Q96Q83 ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 - - 1 1 -
Aluminum 1 - - - -
Q06203 PUR1_HUMAN Amidophosphoribosyltransferase - - 1 - -
P19801 ABP1_HUMAN Amiloride-sensitive amine oxidase [copper-containing] 1 - - 5 -
Q16515 ASIC2_HUMAN Amiloride-sensitive cation channel 1, neuronal 1 - - - -
P78348 ACCN2_HUMAN Amiloride-sensitive cation channel 2, neuronal 2 - - - -
P37088 SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha 2 - - 1 -
P51168 SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta 2 - - - -
P51172 SCNND_HUMAN Amiloride-sensitive sodium channel subunit delta 2 - - - -
P51170 SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma 2 - - - -
P21397 AOFA_HUMAN Amine oxidase [flavin-containing] A 10 - 1 5 -
P27338 AOFB_HUMAN Amine oxidase [flavin-containing] B 9 - 1 41 2
Q03154 ACY1_HUMAN Aminoacylase-1 - - 1 2 -
P48728 GCST_HUMAN Aminomethyltransferase, mitochondrial - - 2 2 -
P15144 AMPN_HUMAN Aminopeptidase N 2 - - 4 -
Q9BXJ7 AMNLS_HUMAN Amnionless protein 1 - - - -
P10275 ANDR_HUMAN Androgen receptor 18 - - 78 20
Q02763 TIE2_HUMAN Angiopoietin-1 receptor 3 - - 11 -
P12821 ACE_HUMAN Angiotensin-converting enzyme 14 - - 28 2
Q9BYF1 ACE2_HUMAN Angiotensin-converting enzyme 2 2 - - 11 -
P04083 ANXA1_HUMAN Annexin A1 3 - - 3 -
P07355 ANXA2_HUMAN Annexin A2 - 1 - 10 -
Q5XXA6 ANO1_HUMAN Anoctamin-1 1 - - - -
Q16671 AMHR2_HUMAN Anti-Muellerian hormone type-2 receptor - - 1 - -
P01008 ANT3_HUMAN Antithrombin-III 8 - - 30 -
ApoB-100 mRNA 1 - - - -
P02649 APOE_HUMAN Apolipoprotein E - 2 - 17 -
P08519 APOA_HUMAN Apolipoprotein(a) 1 - - 12 1
P10415 BCL2_HUMAN Apoptosis regulator Bcl-2 4 - - 15 -
O14727 APAF_HUMAN Apoptotic protease-activating factor 1 - - 1 10 3
P29972 AQP1_HUMAN Aquaporin-1 1 - - 4 -
P09917 LOX5_HUMAN Arachidonate 5-lipoxygenase 11 - 1 5 -
P53608 ARGI_BACCD Arginase 1 - - 5 3
P05089 ARGI1_HUMAN Arginase-1 - - 1 36 -
P78540 ARGI2_HUMAN Arginase-2, mitochondrial - - 2 7 -
Q96A70 AZIN2_HUMAN Arginine decarboxylase - - 1 - -
P04424 ARLY_HUMAN Argininosuccinate lyase - - 1 2 -
P00966 ASSY_HUMAN Argininosuccinate synthase - - 2 1 -
Q5T6L4 Q5T6L4_HUMAN Argininosuccinate synthase (Q5T6L4_HUMAN) - - 1 - -
P00966 ASSY_HUMAN Argininosuccinate synthase (ASSY_HUMAN) - - 1 1 1
P0A6E4 ASSY_ECOLI Argininosuccinate synthase (ASSY_ECOLI) 1 - - 4 2
Q5T6L4 Q5T6L4_HUMAN Argininosuccinate synthase (Q5T6L4_HUMAN) - - 1 - -
P00966 ASSY_HUMAN Argininosuccinate synthase (ASSY_HUMAN) - - 1 1 -
P20711 DDC_HUMAN Aromatic-L-amino-acid decarboxylase 1 - - 3 -
Arsenic 2 - - - -
O43681 ASNA_HUMAN Arsenical pump-driving ATPase - - 1 - -
P35869 AHR_HUMAN Aryl hydrocarbon receptor 5 - 1 - -
P0A5L8 NAT_MYCTO Arylamine N-acetyltransferase 1 - - - -
P07307 ASGR2_HUMAN Asialoglycoprotein receptor 2 - 1 - - -
Asparagine - 2 - - -
P08243 ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] - - 4 - -
O43776 SYNC_HUMAN Asparaginyl-tRNA synthetase, cytoplasmic - - 1 - -
P17174 AATC_HUMAN Aspartate aminotransferase, cytoplasmic - - 3 1 -
P00505 AATM_HUMAN Aspartate aminotransferase, mitochondrial - - 2 - -
P45381 ACY2_HUMAN Aspartoacylase - - 1 8 -
Q96HD9 ACY3_HUMAN Aspartoacylase-2 - - 1 - -
Q9ULA0 DNPEP_HUMAN Aspartyl aminopeptidase - - 1 1 -
P14868 SYDC_HUMAN Aspartyl-tRNA synthetase, cytoplasmic - - 1 1 -
Q6PI48 SYDM_HUMAN Aspartyl-tRNA synthetase, mitochondrial - - 1 1 -
Q12797 ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase - - 2 1 -
P17342 ANPRC_HUMAN Atrial natriuretic peptide clearance receptor - 1 - 4 -
P16066 ANPRA_HUMAN Atrial natriuretic peptide receptor A 5 1 - - -
P20594 ANPRB_HUMAN Atrial natriuretic peptide receptor B 1 1 - - -
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