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DrugBank target: Q9BQB6

DrugBank target: Q9BQB6 (VKOR1_HUMAN)     

Vitamin K epoxide reductase complex subunit 1

Vitamin K1 2,3-epoxide reductase subunit 1.

Function

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:14765195, ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}..

Enzyme

1.1.4.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl- 1,4-naphthoquinone + 1,4-dithiothreitol. {ECO:0000269|PubMed:15879509, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.

Disease(s)

Combined deficiency of vitamin K-dependent clotting factors 2 (VKCFD2) [MIM:607473]: VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. {ECO:0000269|PubMed:14765194}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Coumarin resistance (CMRES) [MIM:122700]: A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti- coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:20946155}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 163 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 5 drugs and and 1 nutraceutical for this target protein:

 

 
Generic name: DB00266 dicumarol
Formula: C19H12O6
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00170 menadione
17Z
Formula: C11H8O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00946 phenprocoumon
Formula: C18H16O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00682 warfarin
RWF
Formula: C19H16O4
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01418 acenocoumarol
Formula: C19H15No6
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00498 phenindione
Formula: C15H10O2
Structure: There are no structures of this molecule in the PDB.

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