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DrugBank target: P38606

DrugBank target: P38606 (VATA_HUMAN)     

V-type proton ATPase catalytic subunit A

V-ATPase 69 kDa subunit, Vacuolar ATPase isoform VA68, Vacuolar proton pump subunit alpha, V-ATPase subunit A.

Function

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..

Enzyme

3.6.3.14   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 617 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

Generic name: DB00630 alendronate
AHD
Formula: C4H13No7P2
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01077 etidronic acid
911
Formula: C2H8O7P2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01133 tiludronate
Formula: C7H9Clo6P2S
Structure: There are no structures of this molecule in the PDB.

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