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DrugBank target: P04818

DrugBank target: P04818 (TYSY_HUMAN)     

Example drug-target structure: 1ju6

( There are 36 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Thymidylate synthase

TS, TSase.

Function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway..

Enzyme

2.1.1.45   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

1ju6
1hvy

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 312 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 8 drugs for this target protein:

 

Generic name: DB00642 pemetrexed
LYA
Formula: C20H21N5O6
Structure: There are 7 PDB structures containing this molecule of which 2 are bound to the above target protein.
 
Generic name: DB00650 leucovorin
Formula: C20H23N7O7
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01101 capecitabine
Formula: C15H22Fn3O6
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00440 trimethoprim
TOP
Formula: C14H18N4O3
Structure: There are 18 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00432 trifluridine
Formula: C10H11F3N2O5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00322 floxuridine
Formula: C9H11Fn2O5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00293 raltitrexed
D16
Formula: C21H22N4O6S
Structure: There are 10 PDB structures containing this molecule of which 2 are bound to the above target protein.
Generic name: DB00441 gemcitabine
GEO
Formula: C9H11F2N3O4
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.

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