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DrugBank target: P07101

DrugBank target: P07101 (TY3H_HUMAN)     

Example structure of target: 2xsn

( There is one structure corresponding to this UniProt sequence in the PDB. )

Tyrosine 3-monooxygenase

Tyrosine 3-hydroxylase, TH.

Function

Plays an important role in the physiology of adrenergic neurons..

Enzyme

1.14.16.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

L-tyrosine + tetrahydrobiopterin + O(2) = L- dopa + 4a-hydroxytetrahydrobiopterin.

Disease(s)

Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407]: A form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA. Note=The disease is caused by mutations affecting the gene represented in this entry.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2xsn
2xsn
2xsn
2xsn

Key:    PfamA domain

Sequence length: 527 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 2 drugs and and 2 nutraceuticals for this target protein:

 

 
Generic name: DB00765 metyrosine
Formula: C10H13No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00360 tetrahydrobiopterin
Formula: C9H15N5O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00120 l-phenylalanine
DPN
Formula: C9H11No2
Structure: There are 72 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00135 l-tyrosine
TYR
Formula: C9H11No3
Structure: There are 804 PDB structures containing this molecule although none are bound to the above target protein.

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