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DrugBank target: P11388

DrugBank target: P11388 (TOP2A_HUMAN)     

Example structure of target: 1lwz

( There are 4 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

DNA topoisomerase 2-alpha

DNA topoisomerase II, alpha isozyme.

Function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes..

Enzyme

5.99.1.3   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1lwz
1zxm
1zxn
4fm9

Key:    PfamA domain

Sequence length: 1530 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 23 drugs for this target protein:

 

Generic name: DB00445 epirubicin
DM6
Formula: C27H29No11
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01137 levofloxacin
LFX
Formula: C18H20Fn3O4
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00773 etoposide
EVP
Formula: C29H32O13
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB04967 lucanthone
Formula: C20H24N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00685 trovafloxacin
Formula: C20H15F3N4O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01059 norfloxacin
Formula: C16H18Fn3O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00694 daunorubicin
DM1
Formula: C27H29No10
Structure: There are 16 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00978 lomefloxacin
Formula: C17H19F2N3O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00537 ciprofloxacin
CPF
Formula: C17H18Fn3O3
Structure: There are 5 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01179 podofilox
POD
Formula: C22H22O8
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00444 teniposide
9TP
Formula: C32H32O13S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00380 dexrazoxane
Formula: C11H16N4O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00997 doxorubicin
DM2
Formula: C27H29No11
Structure: There are 7 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01177 idarubicin
DM5
Formula: C26H27No9
Structure: There are 5 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00218 moxifloxacin
MFX
Formula: C21H24Fn3O4
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01204 mitoxantrone
MIX
Formula: C22H28N4O6
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00487 pefloxacin
Formula: C17H20Fn3O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04576 fleroxacin
Formula:
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01165 ofloxacin
XED
Formula: C18H20Fn3O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00467 enoxacin
Formula: C15H17Fn4O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00385 valrubicin
Formula: C34H36F3No13
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01208 sparfloxacin
Formula: C19H22F2N4O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00276 amsacrine
ASW
Formula: C21H19N3O3S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

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