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DrugBank target: P10828

DrugBank target: P10828 (THB_HUMAN)     

Example drug-target structure: 1y0x

( There are 19 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Thyroid hormone receptor beta

Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta.

Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine..

Disease(s)

Generalized thyroid hormone resistance (GTHR) [MIM:188570]: A disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Note=The disease is caused by mutations affecting the gene represented in this entry.
Generalized thyroid hormone resistance autosomal recessive (GTHRAR) [MIM:274300]: An autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone. Note=The disease is caused by mutations affecting the gene represented in this entry.
Selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]: Variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

1y0x

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

Sequence length: 460 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 4 drugs for this target protein:

 

 
Generic name: DB00509 dextrothyroxine
Formula: C15H11I4No4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00279 liothyronine
_T3
Formula: C15H12I3No4
Structure: There are 14 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01583 liotrix
Formula: C30H21I7N2Na2O8
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00451 levothyroxine
T44
Formula: C15H11I4No4
Structure: There are 21 PDB structures containing this molecule of which 1 is bound to the above target protein.

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