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DrugBank target: P10827

DrugBank target: P10827 (THA_HUMAN)     

Example drug-target structure: 4lnx

( There are 8 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Thyroid hormone receptor alpha

Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, c-erbA-1, c-erbA-alpha, EAR-7.

Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine..

Disease(s)

Hypothyroidism, congenital, non-goitrous, 6 (CHNG6) [MIM:614450]: A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

4lnx

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

Sequence length: 489 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 4 drugs for this target protein:

 

 
Generic name: DB00509 dextrothyroxine
Formula: C15H11I4No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01583 liotrix
Formula: C30H21I7N2Na2O8
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00279 liothyronine
_T3
Formula: C15H12I3No4
Structure: There are 14 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00451 levothyroxine
T44
Formula: C15H11I4No4
Structure: There are 21 PDB structures containing this molecule of which 1 is bound to the above target protein.

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