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DrugBank target: Q9H4B7

DrugBank target: Q9H4B7 (TBB1_HUMAN)     

Tubulin beta-1 chain

Beta-I tubulin.

Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)..

Disease(s)

Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1) [MIM:613112]: A congenital blood disorder characterized by increased platelet size and decreased number of circulating platelets. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 451 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 5 drugs for this target protein:

 

Generic name: DB01394 colchicine
LOC
Formula: C22H25No6
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01248 docetaxel
TXL
Formula: C43H53No14
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB06772 cabazitaxel
Formula: C45H57No14
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01229 paclitaxel
TA1
Formula: C47H51No14
Structure: There are 14 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00309 vindesine
Formula: C43H55N5O7
Structure: There are no structures of this molecule in the PDB.

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