DrugBank target: P51649

DrugBank target: P51649 (SSDH_HUMAN)     

Example drug-target structure: 2w8q

( There are 5 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Succinate-semialdehyde dehydrogenase, mitochondrial

Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase.


Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). {ECO:0000269|PubMed:19300440}..

Enzyme   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.


Succinic semialdehyde dehydrogenase deficiency (SSADHD) [MIM:271980]: A rare inborn error of 4-aminobutyric acid (GABA) metabolism, which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is clinically characterized by developmental delay, hypotonia, mental retardation, ataxia, seizures, hyperkinetic behavior, aggression, and sleep disturbances. {ECO:0000269|PubMed:11243727, ECO:0000269|PubMed:11901270, ECO:0000269|PubMed:14635103}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule


Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 534 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 2 drugs and and 2 nutraceuticals for this target protein:


Generic name: DB00313 valproic acid
Formula: C8H16O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00534 chlormerodrin
Formula: C5H11Clhgn2O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00139 succinic acid
Formula: C4H6O4
Structure: There are 150 PDB structures containing this molecule of which 1 is bound to the above target protein.
Generic name: DB00157 nadh
Formula: C21H29N7O14P2
Structure: There are 161 PDB structures containing this molecule although none are bound to the above target protein.