spacer
spacer

Search 

DrugBank target: P51170

DrugBank target: P51170 (SCNNG_HUMAN)     

Amiloride-sensitive sodium channel subunit gamma

Epithelial Na(+) channel subunit gamma, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG, ENaCG, Gamma-ENaC.

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..

Disease(s)

Liddle syndrome (LIDDS) [MIM:177200]: Autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Note=The disease is caused by mutations affecting the gene represented in this entry.
Bronchiectasis with or without elevated sweat chloride 3 (BESC3) [MIM:613071]: A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 649 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 2 drugs for this target protein:

 

Generic name: DB00594 amiloride
AMR
Formula: C6H8Cln7O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00384 triamterene
DX2
Formula: C12H11N7
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

  spacer

spacer