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DrugBank target: P51172

DrugBank target: P51172 (SCNND_HUMAN)     

Amiloride-sensitive sodium channel subunit delta

Delta-NaCH, Epithelial Na(+) channel subunit delta, Nonvoltage-gated sodium channel 1 subunit delta, SCNED, Delta-ENaC, ENaCD.

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 638 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 2 drugs for this target protein:

 

Generic name: DB00594 amiloride
AMR
Formula: C6H8Cln7O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00384 triamterene
DX2
Formula: C12H11N7
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

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