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DrugBank target: P31645

DrugBank target: P31645 (SC6A4_HUMAN)     

Sodium-dependent serotonin transporter

5HT transporter, Solute carrier family 6 member 4, 5HTT.

Function

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 630 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 39 drugs and and 1 nutraceutical for this target protein:

 

 
Generic name: DB06148 mianserin
Formula: C18H20N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01105 sibutramine
Formula: C17H26Cln
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00579 mazindol
Formula: C16H13Cln2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00215 citalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00661 verapamil
Formula: C27H38N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00514 dextromethorphan
Formula: C18H25No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00543 amoxapine
Formula: C17H16Cln3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00852 pseudoephedrine
Formula: C10H15No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00422 methylphenidate
Formula: C14H19No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00176 fluvoxamine
FVX
Formula: C15H21F3N2O2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00805 minaprine
Formula: C17H22N4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06204 tapentadol
Formula: C14H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01149 nefazodone
Formula: C25H32Cln5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01114 chlorpheniramine
Formula: C16H19Cln2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00907 cocaine
CCA
Formula: C17H21No4
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB06700 desvenlafaxine
Formula: C16H25No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00321 amitriptyline
TP0
Formula: C20H23N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB08918 levomilnacipran
Formula: C15H22N2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01577 methamphetamine
B40
Formula: C10H15N
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00193 tramadol
Formula: C16H25No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00656 trazodone
Formula: C19H22Cln5O
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB06701 dexmethylphenidate
Formula: C14H19No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00344 protriptyline
Formula: C19H21N
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00472 fluoxetine
RFX
Formula: C17H18F3No
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00191 phentermine
Formula: C10H15N
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB01363 ephedra
Formula:
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01104 sertraline
SRE
Formula: C17H17Cl2N
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00540 nortriptyline
21B
Formula: C19H21N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01175 escitalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04896 milnacipran
Formula: C15H22N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00285 venlafaxine
Formula: C17H27No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00458 imipramine
IXX
Formula: C19H24N2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00726 trimipramine
Formula: C20H26N2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01242 clomipramine
CXX
Formula: C19H23Cln2
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00715 paroxetine
8PR
Formula: C19H20Fno3
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01142 doxepin
D7V
Formula: C19H21No
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB01151 desipramine
DSM
Formula: C18H22N2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00289 atomoxetine
Formula: C17H21No
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00476 duloxetine
29E
Formula: C18H19Nos
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01191 dexfenfluramine
Formula: C12H16F3N
Structure: There are no structures of this molecule in the PDB.

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