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DrugBank target: Q01959

DrugBank target: Q01959 (SC6A3_HUMAN)     

Sodium-dependent dopamine transporter

Solute carrier family 6 member 3, DA transporter, DAT.

Function

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals..

Disease(s)

Parkinsonism-dystonia infantile (PKDYS) [MIM:613135]: A neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 620 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 29 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB01576 dextroamphetamine
1WE
Formula: C9H13N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00726 trimipramine
Formula: C20H26N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00422 methylphenidate
Formula: C14H19No2
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB01363 ephedra
Formula:
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00476 duloxetine
29E
Formula: C18H19Nos
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

 

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Generic name: DB06701 dexmethylphenidate
Formula: C14H19No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00191 phentermine
Formula: C10H15N
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00182 amphetamine
FRD
Formula: C9H13N
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01114 chlorpheniramine
Formula: C16H19Cln2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00830 phenmetrazine
Formula: C11H15No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01146 diphenylpyraline
Formula: C19H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01156 bupropion
Formula: C13H18Clno
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01175 escitalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00907 cocaine
CCA
Formula: C17H21No4
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01577 methamphetamine
B40
Formula: C10H15N
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01463 fencamfamine
Formula: C15H21N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01105 sibutramine
Formula: C17H26Cln
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00988 dopamine
LDP
Formula: C8H11No2
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01161 chloroprocaine
Formula: C13H19Cln2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00285 venlafaxine
Formula: C17H27No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00937 diethylpropion
Formula: C13H19No
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01104 sertraline
SRE
Formula: C17H17Cl2N
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01255 lisdexamfetamine
Formula: C15H25N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00579 mazindol
Formula: C16H13Cln2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00745 modafinil
Formula: C15H15No2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00721 procaine
Formula: C13H20N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00852 pseudoephedrine
Formula: C10H15No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00865 benzphetamine
Formula: C17H21N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01149 nefazodone
Formula: C25H32Cln5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00245 benzatropine
Formula: C21H25No
Structure: There are no structures of this molecule in the PDB.

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