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DrugBank target: P31213

DrugBank target: P31213 (S5A2_HUMAN)     

3-oxo-5-alpha-steroid 4-dehydrogenase 2

5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, Type II 5-alpha reductase, S5AR 2.

Function

Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology..

Enzyme

1.3.1.22   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.

Disease(s)

Pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]: A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. {ECO:0000269|PubMed:10718838, ECO:0000269|PubMed:10999800, ECO:0000269|PubMed:1522235, ECO:0000269|PubMed:15528927, ECO:0000269|PubMed:15770495, ECO:0000269|PubMed:16098368, ECO:0000269|PubMed:16181229, ECO:0000269|PubMed:7554313, ECO:0000269|PubMed:8626825, ECO:0000269|PubMed:8768837, ECO:0000269|PubMed:9208814, ECO:0000269|PubMed:9745434, ECO:0000269|PubMed:9843052}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 254 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

Generic name: DB00548 azelaic acid
AZ1
Formula: C9H16O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01126 dutasteride
Formula: C27H30F6N2O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01216 finasteride
FIT
Formula: C23H36N2O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

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