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DrugBank target: P18405

DrugBank target: P18405 (S5A1_HUMAN)

3-oxo-5-alpha-steroid 4-dehydrogenase 1

SR type 1, Steroid 5-alpha-reductase 1, S5AR 1.

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology..

Enzyme

1.3.1.22   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.

Structures

There are currently no structures for this UniProt code in the PDB.

Key:  

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

Generic name: DB00367 levonorgestrel
NOG
Formula: C21H28O2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01216 finasteride
FIT
Formula: C23H36N2O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01126 dutasteride
Formula: C27H30F6N2O2
Structure: There are no structures of this molecule in the PDB.

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