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DrugBank target: P55011

DrugBank target: P55011 (S12A2_HUMAN)     

Solute carrier family 12 member 2

Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1.

Function

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 1212 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

 
Generic name: DB00887 bumetanide
Formula: C17H20N2O5S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01325 quinethazone
Formula: C10H12Cln3O3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00761 potassium chloride
Formula: Clk
Structure: There are no structures of this molecule in the PDB.

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