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DrugBank target: P28702

DrugBank target: P28702 (RXRB_HUMAN)     

Example structure of target: 1h9u

( There are 2 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Retinoic acid receptor RXR-beta

Nuclear receptor subfamily 2 group B member 2, Retinoid X receptor beta.

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA)..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1h9u
1uhl
1h9u
1uhl

Key:    PfamA domain

Sequence length: 532 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 5 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00307 bexarotene
9RA
Formula: C24H28O2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00755 tretinoin
REA
Formula: C20H28O2
Structure: There are 31 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00210 adapalene
Formula: C28H28O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00459 acitretin
Formula: C21H26O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00523 alitretinoin
9CR
Formula: C20H28O2
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00799 tazarotene
Formula: C21H21No2S
Structure: There are no structures of this molecule in the PDB.

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