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DrugBank target: Q6NUM9

DrugBank target: Q6NUM9 (RETST_HUMAN)     

All-trans-retinol 13,14-reductase

All-trans-13,14-dihydroretinol saturase, PPAR-alpha-regulated and starvation-induced gene protein, RetSat.

Function

Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity). {ECO:0000250}..

Enzyme

1.3.99.23   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 610 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00162 vitamin a
RTL
Formula: C20H30O
Structure: There are 25 PDB structures containing this molecule although none are bound to the above target protein.

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