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DrugBank target: Q96IG6

DrugBank target: Q96IG6 (GCST_HUMAN)

Aminomethyltransferase, mitochondrial

Glycine cleavage system T protein, GCVT.

Function

The glycine cleavage system catalyzes the degradation of glycine..

Enzyme

2.1.2.10   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10- methylenetetrahydrofolate + NH(3).

Disease(s)

Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Key:  

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

 
Generic name: DB00116 tetrahydrofolic acid
Formula: C19H23N7O6
Structure: There are no structures of this molecule in the PDB.

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