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DrugBank target: Q02127

DrugBank target: Q02127 (PYRD_HUMAN)     

Example structure of target: 1d3g

( There are 35 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Dihydroorotate dehydrogenase (quinone), mitochondrial

Dihydroorotate oxidase, DHOdehase.

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor..

Enzyme

1.3.5.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

(S)-dihydroorotate + a quinone = orotate + a quinol.

Disease(s)

Postaxial acrofacial dysostosis (POADS) [MIM:263750]: POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1d3g
1d3h
2b0m
2bxv
   more ...

Key:    PfamA domain

Sequence length: 394 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

 
Generic name: DB01117 atovaquone
Formula: C22H19Clo3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01097 leflunomide
Formula: C12H9F3N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08880 teriflunomide
Formula:
Structure: There are no structures of this molecule in the PDB.

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