(S)-dihydroorotate + a quinone = orotate + a quinol.
Postaxial acrofacial dysostosis (POADS) [MIM:263750]: POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases. Note=The disease is caused by mutations affecting the gene represented in this entry.
Schematic diagram of Pfam domains in target sequence
plus wiring diagrams of PDB structures