DrugBank target: Q8N142

DrugBank target: Q8N142 (PURA1_HUMAN)     

Example structure of target: 2gjo

( There is one structure corresponding to this UniProt sequence in the PDB. )

Adenylosuccinate synthetase isozyme 1 {ECO:0000255|HAMAP-Rule:MF_03126}

Adenylosuccinate synthetase, basic isozyme {ECO:0000255|HAMAP-Rule:MF_03126}, Adenylosuccinate synthetase, muscle isozyme {ECO:0000255|HAMAP-Rule:MF_03126}, IMP--aspartate ligase 1 {ECO:0000255|HAMAP-Rule:MF_03126}, AMPSase 1 {ECO:0000255|HAMAP-Rule:MF_03126}, AdSS 1 {ECO:0000255|HAMAP-Rule:MF_03126}, M-type adenylosuccinate synthetase {ECO:0000255|HAMAP-Rule:MF_03126}.


Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}..

Enzyme {ECO:0000255|HAMAP-Rule:MF_03126}   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. {ECO:0000255|HAMAP-Rule:MF_03126}.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure of target.


Key:    PfamA domain

Sequence length: 456 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:


Generic name: DB00128 l-aspartic acid
Formula: C4H7No4
Structure: There are 43 PDB structures containing this molecule although none are bound to the above target protein.