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DrugBank target: P35354

DrugBank target: P35354 (PGH2_HUMAN)     

Example structure of target: 1v0x

( There is one structure corresponding to this UniProt sequence in the PDB. )

Prostaglandin G/H synthase 2

Cyclooxygenase-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, COX-2, PGH synthase 2, PGHS-2.

Function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis..

Enzyme

1.14.99.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1v0x
1v0x
1v0x
1v0x

Key:    PfamA domain

Sequence length: 603 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 46 drugs and and 3 nutraceuticals for this target protein:

 

Generic name: DB00586 diclofenac
DIF
Formula: C14H11Cl2No2
Structure: There are 11 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00936 salicyclic acid
SAL
Formula: C7H6O3
Structure: There are 39 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00963 bromfenac
27R
Formula: C15H12Brno3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB04552 niflumic acid
NFL
Formula: C13H9F3N2O2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

 

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Generic name: DB01401 trisalicylate-choline
Formula: C26H29Mgno10
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08910 pomalidomide
Formula: C13H11N3O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00784 mefenamic acid
ID8
Formula: C15H15No2
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01398 salicylate-sodium
Formula: C7H5Nao3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06802 nepafenac
Formula: C15H14N2O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00821 carprofen
0LA
Formula: C15H12Clno2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01050 ibuprofen
IBP
Formula: C13H18O2
Structure: There are 10 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00861 diflunisal
1FL
Formula: C13H8F2O3
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01014 balsalazide
BLQ
Formula: C17H15N3O6
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00749 etodolac
Formula: C17H21No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00554 piroxicam
Formula: C15H13N3O4S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00482 celecoxib
CEL
Formula: C17H14F3N3O2S
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01009 ketoprofen
Formula: C16H14O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01600 tiaprofenic acid
Formula: C14H12O3S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00316 acetaminophen
TYL
Formula: C8H9No2
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00795 sulfasalazine
SAS
Formula: C18H14N4O5S
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB06725 lornoxicam
Formula: C13H10Cln3O4S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00991 oxaprozin
Formula: C18H15No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01399 salsalate
Formula: C14H10O5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00945 acetylsalicylic acid
AIN
Formula: C9H8O4
Structure: There are 8 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00469 tenoxicam
Formula: C13H11N3O4S2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00500 tolmetin
TLT
Formula: C15H15No3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00480 lenalidomide
Formula: C13H13N3O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01628 etoricoxib
5CH
Formula: C18H15Cln2O2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01435 antipyrine
Formula: C11H12N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00244 mesalazine
Formula: C7H7No3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00465 ketorolac
KTR
Formula: C15H13No3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01419 antrafenine
Formula: C30H26F6N4O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00939 meclofenamic acid
JMS
Formula: C14H11Cl2No2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00788 naproxen
NPS
Formula: C14H14O3
Structure: There are 8 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00328 indomethacin
IMN
Formula: C19H16Clno4
Structure: There are 26 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00159 icosapent
EPA
Formula: C20H30O2
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00605 sulindac
SUZ
Formula: C20H17Fo3S
Structure: There are 8 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00812 phenylbutazone
P1Z
Formula: C19H20N2O2
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00154 gamma-homolinolenic acid
LAX
Formula: C20H34O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00233 aminosalicylic acid
BHA
Formula: C7H7No3
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01041 thalidomide
Formula: C13H10N2O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00461 nabumetone
NBO
Formula: C15H16O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00814 meloxicam
MXM
Formula: C14H13N3O4S2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01283 lumiracoxib
LUR
Formula: C15H13Clfno2
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.

 

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Generic name: DB01397 magnesium salicylate
Formula: C14H10Mgo6
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00573 fenoprofen
PFN
Formula: C15H14O3
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00870 suprofen
Formula: C14H12O3S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00712 flurbiprofen
FLP
Formula: C15H13Fo2
Structure: There are 10 PDB structures containing this molecule although none are bound to the above target protein.

 

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Generic name: DB01404 ginseng
Formula:
Structure: There are no structures of this molecule in the PDB.

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