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DrugBank target: O76074

DrugBank target: O76074 (PDE5A_HUMAN)     

Example drug-target structure: 1udu

( There are 34 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

cGMP-specific 3',5'-cyclic phosphodiesterase

cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE.

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP..

Enzyme

3.1.4.35   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

1udu
1tbf
1uho

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 874 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 8 drugs for this target protein:

 

Generic name: DB00277 theophylline
TEP
Formula: C7H8N4O2
Structure: There are 6 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00975 dipyridamole
Formula: C24H40N8O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00820 tadalafil
CIA
Formula: C22H19N3O4
Structure: There are 2 PDB structures containing this molecule and all are bound to the above target protein.
 
Generic name: DB06237 avanafil
Formula: C23H26Cln7O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00203 sildenafil
VIA
Formula: C22H30N6O4S
Structure: There are 5 PDB structures containing this molecule of which 4 are bound to the above target protein.
 
Generic name: DB06267 udenafil
Formula: C25H36N6O4S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00862 vardenafil
VDN
Formula: C23H32N6O4S
Structure: There are 4 PDB structures containing this molecule of which 3 are bound to the above target protein.
Generic name: DB00806 pentoxifylline
PNX
Formula: C13H18N4O3
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.

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