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DrugBank target: Q14432

DrugBank target: Q14432 (PDE3A_HUMAN)     

Example structure of target: 1lrc

( There is one structure corresponding to this UniProt sequence in the PDB. )

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Cyclic GMP-inhibited phosphodiesterase A, CGI-PDE A.

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity)..

Enzyme

3.1.4.17   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1lrc
1lrc
1lrc
1lrc

Key:    PfamA domain  PfamB domain

Sequence length: 1140 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 11 drugs for this target protein:

 

 
Generic name: DB00261 anagrelide
Formula: C10H7Cl2N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01427 amrinone
Formula: C10H9N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00922 levosimendan
Formula: C14H12N6O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00277 theophylline
TEP
Formula: C7H8N4O2
Structure: There are 6 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01166 cilostazol
Formula: C20H27N5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01223 aminophylline
Formula: C16H24N10O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08811 tofisopam
Formula: C22H26N2O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00235 milrinone
MIL
Formula: C12H9N3O
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01303 oxtriphylline
Formula: C12H21N5O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB05266 ibudilast
AVL
Formula: C14H18N2O
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB04880 enoximone
Formula: C12H12N2O2S
Structure: There are no structures of this molecule in the PDB.

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