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DrugBank target: P41143

DrugBank target: P41143 (OPRD_HUMAN)     

Example structure of target: 1ozc

( There are 2 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Delta-type opioid receptor

D-OR-1, DOR-1.

Function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1ozc
1ozc
1ozc
1ozc

Key:    PfamA domain

Sequence length: 371 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 24 drugs for this target protein:

 

 
Generic name: DB00318 codeine
Formula: C18H21No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00704 naltrexone
Formula: C20H23No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00854 levorphanol
Formula: C17H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00497 oxycodone
Formula: C18H21No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00844 nalbuphine
Formula: C21H27No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00956 hydrocodone
Formula: C18H21No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00708 sufentanil
Formula: C22H30N2O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01081 diphenoxylate
Formula: C30H32N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00647 propoxyphene
Formula: C22H29No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06274 alvimopan
Formula: C25H32N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06204 tapentadol
Formula: C14H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00327 hydromorphone
Formula: C17H19No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00899 remifentanil
Formula: C20H28N2O5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00193 tramadol
Formula: C16H25No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00333 methadone
Formula: C21H27No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01192 oxymorphone
Formula: C17H19No4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00295 morphine
MOI
Formula: C17H19No3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01452 heroin
Formula: C21H23No5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00321 amitriptyline
TP0
Formula: C20H23N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00813 fentanyl
Formula: C22H28N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01183 naloxone
Formula: C19H21No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00921 buprenorphine
Formula: C29H41No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00836 loperamide
Formula: C29H33Cln2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00611 butorphanol
Formula: C21H29No2
Structure: There are no structures of this molecule in the PDB.

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