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DrugBank target: Q96RI1

DrugBank target: Q96RI1 (NR1H4_HUMAN)     

Example structure of target: 1osh

( There are 24 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Bile acid receptor

Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14.

Function

Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1osh
1osk
3bej
3dct
   more ...

Key:    PfamA domain  PfamB domain

Sequence length: 485 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

Generic name: DB06777 chenodeoxycholic acid
JN3
Formula: C24H40O4
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

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