There are 24 structures corresponding
to this UniProt sequence in the PDB. Click the orange, plus icon above
for a list.
Bile acid receptor
Farnesoid X-activated receptor,
Farnesol receptor HRR-1,
Nuclear receptor subfamily 1 group H member 4,
Retinoid X receptor-interacting protein 14,
RXR-interacting protein 14.
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus..
Schematic diagram of Pfam domains in target sequence
plus wiring diagrams of PDB structures