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DrugBank target: O43451

DrugBank target: O43451 (MGA_HUMAN)     

Example drug-target structure: 3l4w

( There are 12 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Maltase-glucoamylase, intestinal

Maltase, Alpha-glucosidase, Glucoamylase, Glucan 1,4-alpha-glucosidase.

Function

May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing..

Enzyme

3.2.1.20   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
3.2.1.3   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)- linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal (1->4)-linked alpha-D- glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

3l4w

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

Sequence length: 1856 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

 
Generic name: DB04878 voglibose
Formula: C10H21No7
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00491 miglitol
MIG
Formula: C8H17No5
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.
 
Generic name: DB00284 acarbose
Formula: C25H43No18
Structure: There are no structures of this molecule in the PDB.

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