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DrugBank target: P08235

DrugBank target: P08235 (MCR_HUMAN)     

Example drug-target structure: 1ya3

( There are 17 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Mineralocorticoid receptor

Nuclear receptor subfamily 3 group C member 2, MR.

Function

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}..

Disease(s)

Pseudohypoaldosteronism 1, autosomal dominant (PHA1A) [MIM:177735]: A salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1A is a mild form characterized by target organ defects confined to kidney. Patients may present with neonatal renal salt wasting with hyperkalaemic acidosis despite high aldosterone levels. These patients improve with age and usually become asymptomatic without treatment. {ECO:0000269|PubMed:16972228}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Early-onset hypertension with severe exacerbation in pregnancy (EOHSEP) [MIM:605115]: Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion. {ECO:0000269|PubMed:10884226}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

1ya3
2ab2

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 983 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 8 drugs for this target protein:

 

Generic name: DB00396 progesterone
STR
Formula: C21H30O2
Structure: There are 21 PDB structures containing this molecule of which 3 are bound to the above target protein.
Generic name: DB00421 spironolactone
SNL
Formula: C24H32O4S
Structure: There are 3 PDB structures containing this molecule and all are bound to the above target protein.
 
Generic name: DB00588 fluticasone propionate
Formula: C25H31F3O5S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01395 drospirenone
Formula: C24H30O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00393 nimodipine
Formula: C21H26N2O7
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00700 eplerenone
Formula: C24H30O6
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01023 felodipine
225
Formula: C18H19Cl2No4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00687 fludrocortisone
ZK5
Formula: C21H29Fo5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

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