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DrugBank target: P09917

DrugBank target: P09917 (LOX5_HUMAN)     

Example structure of target: 2abv

( There are 5 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Arachidonate 5-lipoxygenase

5-LO, 5-lipoxygenase.

Function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes..

Enzyme

1.13.11.34   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Arachidonate + O(2) = leukotriene A(4) + H(2)O.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2abv
3o8y
3v92
3v98
   more ...

Key:    PfamA domain

Sequence length: 673 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 11 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00795 sulfasalazine
SAS
Formula: C18H14N4O5S
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00244 mesalazine
Formula: C7H7No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00179 masoprocol
Formula: C18H22O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00939 meclofenamic acid
JMS
Formula: C14H11Cl2No2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00233 aminosalicylic acid
BHA
Formula: C7H7No3
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00471 montelukast
MTK
Formula: C35H36Clno3S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB01014 balsalazide
BLQ
Formula: C17H15N3O6
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00163 vitamin e
VIT
Formula: C29H50O2
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00744 zileuton
Formula: C11H12N2O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00711 diethylcarbamazine
Formula: C10H21N3O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01017 minocycline
MIY
Formula: C23H27N3O7
Structure: There are 8 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00586 diclofenac
DIF
Formula: C14H11Cl2No2
Structure: There are 11 PDB structures containing this molecule although none are bound to the above target protein.

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