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DrugBank target: Q12809

DrugBank target: Q12809 (KCNH2_HUMAN)     

Example structure of target: 1byw

( There are 8 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Potassium voltage-gated channel subfamily H member 2

Eag homolog, Ether-a-go-go-related gene potassium channel 1, Voltage-gated potassium channel subunit Kv11.1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1.

Function

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation..

Disease(s)

Long QT syndrome 2 (LQT2) [MIM:613688]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Deafness is often associated with long QT syndrome type 2. Note=The disease is caused by mutations affecting the gene represented in this entry.
Short QT syndrome 1 (SQT1) [MIM:609620]: A heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. It causes syncope and sudden death. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1byw
1ujl
2l0w
2l1m
   more ...

Key:    PfamA domain  PfamB domain

Sequence length: 1158 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 21 drugs for this target protein:

 

 
Generic name: DB01218 halofantrine
Formula: C26H30Cl2F3No
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00457 prazosin
XRA
Formula: C19H21N5O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00590 doxazosin
Formula: C23H25N5O5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01118 amiodarone
Formula: C25H29I2No3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00276 amsacrine
ASW
Formula: C21H19N3O3S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01162 terazosin
Formula: C19H25N5O4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01136 carvedilol
CVD
Formula: C24H26N2O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00604 cisapride
Formula: C23H29Clfn3O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06144 sertindole
Formula: C24H26Clfn4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00204 dofetilide
Formula: C19H27N3O5S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01182 propafenone
Formula: C21H27No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00489 sotalol
Formula: C12H20N2O3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00637 astemizole
Formula: C28H31Fn4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01110 miconazole
Formula: C18H14Cl4N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00342 terfenadine
Formula: C32H41No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00908 quinidine
Formula: C20H24N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00308 ibutilide
Formula: C20H36N2O3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00661 verapamil
Formula: C27H38N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04855 dronedarone
Formula: C31H44N2O5S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00679 thioridazine
LZU
Formula: C21H26N2S2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01100 pimozide
Formula: C28H29F2N3O
Structure: There are no structures of this molecule in the PDB.

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