spacer
spacer

Search 

DrugBank target: Q14654

DrugBank target: Q14654 (IRK11_HUMAN)     

ATP-sensitive inward rectifier potassium channel 11

IKATP, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11.

Function

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO:0000250, ECO:0000269|PubMed:17855752, ECO:0000269|PubMed:9831708}..

Disease(s)

Familial hyperinsulinemic hypoglycemia 2 (HHF2) [MIM:601820]: Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. {ECO:0000269|PubMed:10204114, ECO:0000269|PubMed:12364426, ECO:0000269|PubMed:15562009, ECO:0000269|PubMed:15579781, ECO:0000269|PubMed:15807877, ECO:0000269|PubMed:15998776, ECO:0000269|PubMed:16332676, ECO:0000269|PubMed:16357843, ECO:0000269|PubMed:7847376, ECO:0000269|PubMed:8923010}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood- onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. {ECO:0000269|PubMed:15115830, ECO:0000269|PubMed:15292329, ECO:0000269|PubMed:15448106, ECO:0000269|PubMed:15448107, ECO:0000269|PubMed:15580558, ECO:0000269|PubMed:16609879, ECO:0000269|PubMed:16731833, ECO:0000269|PubMed:17213273}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Transient neonatal diabetes mellitus 3 (TNDM3) [MIM:610582]: Neonatal diabetes mellitus, defined as insulin- requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. {ECO:0000269|PubMed:15718250, ECO:0000269|PubMed:15784703}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Note=Defects in KCNJ11 may contribute to non-insulin- dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 390 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 7 drugs for this target protein:

 

Generic name: DB01119 diazoxide
20J
Formula: C8H7Cln2O2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00661 verapamil
Formula: C27H38N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00922 levosimendan
Formula: C14H12N6O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01016 glyburide
Formula: C23H28Cln3O5S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00308 ibutilide
Formula: C20H36N2O3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01154 thiamylal
Formula: C12H18N2O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00222 glimepiride
Formula: C24H34N4O5S
Structure: There are no structures of this molecule in the PDB.

  spacer

spacer