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DrugBank target: P35367

DrugBank target: P35367 (HRH1_HUMAN)     

Example structure of target: 3rze

( There is one structure corresponding to this UniProt sequence in the PDB. )

Histamine H1 receptor

H1R, HH1R.

Function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system..

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 487 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 79 drugs for this target protein:

 

 
Generic name: DB00792 tripelennamine
Formula: C16H21N3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01238 aripiprazole
Formula: C23H27Cl2N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00748 carbinoxamine
Formula: C16H19Cln2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01176 cyclizine
Formula: C18H22N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06148 mianserin
Formula: C18H20N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00366 doxylamine
Formula: C17H22N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00950 fexofenadine
Formula: C32H39No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01619 phenindamine
Formula: C19H19N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01114 chlorpheniramine
Formula: C16H19Cln2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01084 emedastine
Formula: C17H26N4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00363 clozapine
Formula: C18H19Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06691 mepyramine
Formula: C17H23N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01069 promethazine
Formula: C17H20N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00341 cetirizine
Formula: C21H25Cln2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00557 hydroxyzine
Formula: C21H27Cln2O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00420 promazine
P2Z
Formula: C17H20N2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00767 benzquinamide
Formula: C22H32N2O5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB08800 chloropyramine
C4C
Formula: C16H20Cln3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01620 pheniramine
Formula: C16H20N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00215 citalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01151 desipramine
DSM
Formula: C18H22N2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01237 bromodiphenhydramine
Formula: C17H20Brno
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00540 nortriptyline
21B
Formula: C19H21N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00719 azatadine
Formula: C20H22N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00667 histamine phosphate
Formula: C5H15N3O8P2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01615 aceprometazine
Formula: C19H22N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00737 meclizine
Formula: C25H27Cln2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00726 trimipramine
Formula: C20H26N2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01075 diphenhydramine
2PM
Formula: C17H21No
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00768 olopatadine
Formula: C21H23No3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00477 chlorpromazine
Z80
Formula: C17H19Cln2S
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00354 buclizine
Formula: C28H33Cln2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00920 ketotifen
Formula: C19H19Nos
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00283 clemastine
Formula: C21H26Clno
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00777 propiomazine
Formula: C20H24N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01224 quetiapine
Formula: C21H25N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00405 dexbrompheniramine
Formula: C16H19Brn2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01267 paliperidone
Formula: C23H27Fn4O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00321 amitriptyline
TP0
Formula: C20H23N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01239 chlorprothixene
Formula: C18H18Clns
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00967 desloratadine
Formula: C19H19Cln2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00835 brompheniramine
Formula: C16H19Brn2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00568 cinnarizine
Formula: C26H28N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01403 methotrimeprazine
Formula: C19H24N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00334 olanzapine
Formula: C17H20N4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06766 alcaftadine
Formula: C19H21N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00342 terfenadine
Formula: C32H41No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00455 loratadine
Formula: C22H23Cln2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08802 isothipendyl
Formula: C16H19N3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06216 asenapine
Formula: C21H20Clno5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00246 ziprasidone
Formula: C21H21Cln4Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00637 astemizole
Formula: C28H31Fn4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00797 tolazoline
Formula: C10H12N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08801 dimethindene
Formula: C20H24N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08799 antazoline
Formula: C17H19N3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00458 imipramine
IXX
Formula: C19H24N2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01106 levocabastine
Formula: C26H29Fn2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00985 dimenhydrinate
Formula: C24H28Cln5O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00656 trazodone
Formula: C19H22Cln5O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01173 orphenadrine
Formula: C18H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01146 diphenylpyraline
Formula: C19H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04946 iloperidone
Formula: C24H27Fn2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00751 epinastine
Formula: C16H15N3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01071 mequitazine
Formula: C20H22N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01175 escitalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01142 doxepin
D7V
Formula: C19H21No
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB04837 chlophedianol
Formula: C17H20Clno
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04841 flunarizine
Formula: C26H26F2N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00370 mirtazapine
Formula: C17H19N3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00972 azelastine
Formula: C22H24Cln3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00902 methdilazine
Formula: C18H20N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01246 trimeprazine
Formula: C18H22N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00434 cyproheptadine
Formula: C21H21N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04890 bepotastine
Formula: C21H25Cln2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00427 triprolidine
Formula: C19H22N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00934 maprotiline
Formula: C20H23N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00734 risperidone
Formula: C23H27Fn4O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00245 benzatropine
Formula: C21H25No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06698 betahistine
Formula: C8H12N2
Structure: There are no structures of this molecule in the PDB.

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