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DrugBank target: P32754

DrugBank target: P32754 (HPPD_HUMAN)     

Example structure of target: 3isq

( There is one structure corresponding to this UniProt sequence in the PDB. )

4-hydroxyphenylpyruvate dioxygenase

4-hydroxyphenylpyruvic acid oxidase, 4HPPD, HPD, HPPDase.

Function

Key enzyme in the degradation of tyrosine..

Enzyme

1.13.11.27   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).

Disease(s)

Tyrosinemia 3 (TYRSN3) [MIM:276710]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Note=The disease is caused by mutations affecting the gene represented in this entry.
Hawkinsinuria (HAWK) [MIM:140350]: An inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure of target.

3isq

Key:    PfamA domain

Sequence length: 392 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

 
Generic name: DB00348 nitisinone
Formula: C14H10F3No5
Structure: There are no structures of this molecule in the PDB.

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