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DrugBank target: P04035

DrugBank target: P04035 (HMDH_HUMAN)     

Example drug-target structure: 1hwl

( There are 36 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

3-hydroxy-3-methylglutaryl-coenzyme A reductase

HMG-CoA reductase.

Function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins..

Enzyme

1.1.1.34   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

(R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

1hwl
1hwk
1hwi

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

Sequence length: 887 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 7 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 156 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00175 pravastatin
Formula: C23H36O7
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00227 lovastatin
803
Formula: C24H36O5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB08860 pitavastatin
Formula: C25H24Fno4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01098 rosuvastatin
FBI
Formula: C22H28Fn3O6S
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.
Generic name: DB01076 atorvastatin
117
Formula: C33H35Fn2O5
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.
 
Generic name: DB00641 simvastatin
Formula: C25H38O5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01095 fluvastatin
115
Formula: C24H26Fno4
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.

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